Evidence map›Paper›PMID 39394802›Full record

ReviewPest management science2025

Investigation of acetyl-CoA carboxylase-inhibiting herbicides that exhibit soybean crop selectivity.

Stephanie Lee, China Payne, Shaun Rees, Hartmut Ahrens, Lars Arve, Elisabeth Asmus, Guido Bojack, Estel la Buscató Arsequell, Elmar Gatzweiler, Hendrik Helmke and 9 more

Abstract readReview
In one paragraph

Review in Pest management science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Stephanie Lee *Research and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
China Payne *Research and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.ORCID https://orcid.org/0000-0001-7031-8397
Shaun Rees *Research and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
Hartmut AhrensResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
Lars ArveResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
Elisabeth AsmusResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
Guido BojackResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
Estel la Buscató ArsequellResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
Elmar GatzweilerResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
Hendrik HelmkeResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
Christopher KallusResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
Bernd LaberResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
Gudrun LangeResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
Stefan LehrResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
Hubert MenneResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
Christopher H RosingerResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
Wolfgang SchulteResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
Kai SommerResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.
David M BarberResearch and Development, Weed Control Research, Bayer AG, Crop Science Division, Industriepark Höchst, Frankfurt am Main, Germany.ORCID https://orcid.org/0000-0001-9906-1695

Funding

Grains Research and Development Corporation
6 · The paper itself

Abstract

The sustainable control of weed populations, particularly resistant species, is a significant challenge in agriculture around the world. The α-aryl-keto-enol (aryl-KTE) class of acetyl-CoA carboxylase (ACCase)-inhibiting herbicides represent a possible solution for the control of resistant grasses even though achieving crop selectivity remains a challenge. Herein, we present some of our investigations into identifying the most promising structural features within the aryl-KTE class that give the highest chance of achieving soybean crop selectivity, whilst also maintaining strong and broad efficacy against problematic weed species. We further examined our results by preparing new aryl-KTE molecules which were evaluated in glasshouse screening assays for their herbicidal efficacy as well as their soybean selectivity. We consider that uniting this approach with other optimization criteria, such as toxicological and environmental safety profiles, will enable the streamlining of crop protection optimizations programmes, ultimately delivering safer and more sustainable solutions to farmers and consumers. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

Acetyl-CoA CarboxylaseEnzyme InhibitorsGlycine maxHerbicidesPlant WeedsWeed ControlHerbicide ResistanceAcetyl-CoA CarboxylaseEnzyme InhibitorsHerbicidesACCaseacetyl‐CoA carboxylasearyl‐keto‐enolcrop protectionherbicidessoybean selectivitystructure–activity relationshipweed resistance

Identifiers

PMID39394802
PMCPMC11981983

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.