Evidence map›Paper›PMID 39394788›Full record

ArticleThe Journal of clinical endocrinology and metabolism2025

Higher FSH Level Is Associated With Increased Risk of Incident Hip Fracture in Older Adults, Independent of Sex Hormones.

Eileen H Koh, Susan K Ewing, Sigurdur Sigurdsson, Vilmundur Gudnason, Trisha F Hue, Eric Vittinghoff, Claes Ohlsson, Åsa Tivesten, Louise Grahnemo, Tony Yuen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. FSH Signaling in Osteoporosis and Alzheimer's Disease.Current osteoporosis reports · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Eileen H KohDepartment of Medicine, University of Washington, Seattle, WA 98195, USA.ORCID 0009-0009-6916-4816
Susan K EwingDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158, USA.
Sigurdur SigurdssonIcelandic Heart Association Research Institute, 201 Kopavogur, Iceland.
Vilmundur GudnasonIcelandic Heart Association Research Institute, 201 Kopavogur, Iceland.
Trisha F HueDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158, USA.
Eric VittinghoffDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-8535-0920
Claes OhlssonDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.ORCID 0000-0002-9633-2805
Åsa TivestenWallenberg Laboratory for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden.
Louise GrahnemoDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.ORCID 0000-0001-5276-6612
Tony YuenCenter for Translational Medicine and Pharmacology and Mount Sinai Bone Program, and Departments of Medicine and Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Mone ZaidiCenter for Translational Medicine and Pharmacology and Mount Sinai Bone Program, and Departments of Medicine and Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Clifford J RosenCenter for Clinical and Translational Science, MaineHealth Institute for Research, Scarborough, ME 04074, USA.
Ann V SchwartzDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-4529-1641
Anne L SchaferDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158, USA.

Funding

Targeting FSH for the Therapy of Osteoporosis, Obesity and NeurodegenerationU19AG060917 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CLIFFORD JAMES ROSEN, Mone Zaidi · 2019 to 2026
$29.0M
THE PURPOSE OF MODIFICATION TO(1)INCREASE EFFORT OF OPTION 2 AND OPTION 3 FOR ICN01AG12100 · NIA · ICELANDIC HEART ASSOCIATION · PI GUDNASON, VILMUNDUR · 2007 to 2012
$18.4M
DIABETES, ENDOCRINOLOGY &METABOLISM TRAINING PROGRAMT32DK007418 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 1986 to 2026
$14.3M
Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wenhan Chang · 2019 to 2026
$7.1M
Longitudinal changes in marrow fat, other fat depots and boneR01AR065645 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, XIAOJUAN, SCHWARTZ, ANN V · 2014 to 2017
$2.2M
Bone Marrow Adiposity, Bone and Body CompositionR01AR057819 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, XIAOJUAN, SCHWARTZ, ANN V · 2010 to 2012
$1.7M
AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-26012100N01AG012100 · NIA · ICELANDIC HEART ASSOCIATION · 2002 to 2004
–
NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association)NIAMS NIH HHS P30 AR075055NIAMS NIH HHS P30AR075055NIAMS NIH HHS R01 AR057819NIAMS NIH HHS R01AR057819NIAMS NIH HHS R01 AR065645NIAMS NIH HHS R01AR065645NIA NIH HHS N01 AG012100NIA NIH HHS N01AG12100NIA NIH HHS U19 AG060917NIA NIH HHS U19AG060917NIDDK NIH HHS T32 DK007418NIDDK NIH HHS T32DK007418the Althingi (Icelandic Parliament)
6 · The paper itself

Abstract

contextHigher levels of FSH are associated with bone loss among women during the perimenopausal transition and among older men, independent of estradiol and testosterone levels, but whether higher FSH is an independent fracture risk factor is unknown.

objectiveTo determine whether baseline FSH level predicts subsequent hip fracture in older adults. SETTING, DESIGN,

participantsUsing a case-cohort design, we randomly sampled 295 participants stratified by sex from the Age, Gene/Environment Susceptibility-Reykjavik cohort, including 25 participants with incident hip fracture within 10 years after baseline. We sampled an additional 230 sex-stratified participants with incident hip fracture. Serum FSH and sex hormone levels were measured at baseline. Robust weighted Cox proportional hazards models were used to determine the relationship between FSH and hip fracture risk. MAIN OUTCOME: Incident hip fracture.

resultsAs no interaction was identified between FSH and sex for the relationship with fracture, men and women were pooled for analysis. Higher levels of FSH were associated with a significantly increased risk of incident hip fracture in models adjusted for age and sex [hazard ratio (HR) 1.24 (95% CI 1.04-1.48, P = .02)] and after further adjustment for estradiol, testosterone, and SHBG levels [HR 1.20 (95% CI 1.01-1.44, P = .04) per sex-specific SD increase in FSH level].

conclusionHigher FSH is associated with an increased risk of subsequent hip fracture. Our findings support a growing body of evidence for the direct pleiotropic effects of FSH on bone and for a role for FSH in aging and disability independent of sex hormone levels.

Indexed as

Follicle Stimulating HormoneGonadal Steroid HormonesHip FracturesAgedAged, 80 and overCase-Control StudiesCohort StudiesFemaleHumansIcelandIncidenceMaleMiddle AgedProportional Hazards ModelsRisk FactorsTestosteroneFollicle Stimulating HormoneGonadal Steroid HormonesTestosteroneagingfracture riskFSHosteoporosis

Identifiers

PMID39394788
PMCPMC12187201

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.