Evidence map›Paper›PMID 39394716›Full record

ArticleAnnals of clinical and translational neurology2024

Gait speed after mild stroke/transient ischemic attack was associated with long-term adverse outcomes: A cohort study.

Ning Li, Jia Zhang, Yang Du, Jing Li, Anxin Wang, Xingquan Zhao

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Article in Annals of clinical and translational neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ning LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jia ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yang DuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jing LiChina National Clinical Research Center for Neurological Diseases, Beijing, China.
Anxin WangChina National Clinical Research Center for Neurological Diseases, Beijing, China.
Xingquan ZhaoDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-8345-5147

Funding

Capital Medical University Scientific Research Cultivating Funding PYZ23121National Natural Science Foundation of China 82371302National Science and Technology Major Project 2022ZD0118003
6 · The paper itself

Abstract

objectiveThe association between gait speed and adverse outcomes after stroke has not been fully illustrated. This study aimed to explore the association of gait speed on long-term outcomes in minor stroke or transient ischemic attack (TIA).

methodsWe performed a longitudinal study with acute minor stroke or TIA based on a subgroup of the Third China National Stroke Registry data. The gait speed was evaluated using a 10-meter walking test at discharge and 3 months after the stroke onset. The primary outcomes were poor functional outcomes at 1 year, defined by a modified Rankin Score (mRS) of 2-6. Additional outcomes included all-cause death, ambulate dependency (mRS score 4-6), cognitive impairment (Montreal Cognitive Assessment <26), stroke recurrence, and composite vascular events.

resultsThe study sample included a total of 1542 stroke patients with a median age of 60 (53-68). At 1-year follow-up, 140 (9.20%) patients experienced poor functional outcomes. Faster gait speed at discharge was associated with lower incidence of poor functional outcome (OR = 0.89; 95% CI, 0.84-0.94), cognitive impairment (OR = 0.93; 95% CI, 0.89-0.96), ischemic stroke recurrence (HR = 0.92; 95% CI, 0.87-0.98), and composite vascular events (HR =0.94; 95% CI, 0.89-0.99) at 1 year. Faster gait speed at 3 months was associated with lower incidence of poor functional outcome (OR = 0.90; 95% CI, 0.85-0.95), ambulate dependency (OR = 0.86; 95% CI, 0.77-0.97), and cognitive impairment (OR = 0.92; 95% CI, 0.88-0.95) at 1 year.

interpretationOur findings indicated that slow gait speed after minor stroke or TIA may be an independent predictor for long-term poor outcomes. Gait speed may be considered as a vital sign during follow-up in post-stroke patients.

Indexed as

Ischemic Attack, TransientStrokeWalking SpeedAgedChinaCognitive DysfunctionCohort StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedRegistries

Identifiers

PMID39394716
PMCPMC11651184

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