ArticleNature immunology2024
Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T
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Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
–field-weighted citation impact
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Progenitor T cells drive chronic pulmonary type 2 inflammation.Nature immunology · 2026Article
- Aberrant mucin expression and keratinization distinguishing severe from mild asthma revealed by interpretable machine learning.JCI insight · 2026Article
- Pathogenic type-2 immunity beyond allergy: the role of Th2 cell heterogeneity in helminth infections.Infection and immunity · 2026Review
- A unified network systems approach uncovers a core program underlying T follicular helper cell differentiation.Nature communications · 2026Article
- Article
- Review
- IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma.Nature immunology · 2026Article
- Spatial transcriptomic profiling of developing mouse hearts reveals a spatially patterned signaling environment.Communications biology · 2026Article
- Type 2 conventional dendritic cells and regulatory T cells form a barrier tissue circuit to control allergic inflammation.bioRxiv : the preprint server for biology · 2026Article
- Atypical pericapillary Ly6G⁺Nur77⁺ macrophages initiate type-2 immune responses to allergens in the mouse lung.Nature communications · 2026Article
- Dendritic Cell Organization and Function in Innate and Adaptive Immune Defense Within Lymph Nodes.Immunological reviews · 2026Review
- Emerging immune networks and targeted strategies in T2 asthma.Frontiers in immunology · 2026Review
- The Potential Value of Blood Inflammatory Parameters in Diagnosing the Inflammatory Microenvironment and Predicting Fetal Outcomes in Patients With Intrahepatic Cholestasis of Pregnancy.Mediators of inflammation · 2026Article
- Innovations in pediatric lung health amid global health shifts.World journal of pediatrics : WJP · 2025Article
- Functional Specialization and Collaboration of cDC2 Subsets in CD4+ T Cell Priming and Differentiation.Immunological reviews · 2025Review
- Antigen-presenting cells as arbiters of mucosal tolerance and immunity.Nature immunology · 2025Review
- Ontogenetic Diversification of Type 2 Conventional Dendritic Cells in the Bone Marrow: A Central Logic for Peripheral Immunity.Immunological reviews · 2025Review
- Interpretable machine learning coupled to spatial transcriptomics unveils mechanisms of macrophage-driven fibroblast activation in ischemic cardiomyopathy.medRxiv : the preprint server for health sciences · 2025Article
- The immunology of asthma.Nature immunology · 2025Review
- The immunology of asthma and chronic rhinosinusitis.Nature reviews. Immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Kun HeDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Hanxi XiaoCenter for Systems Immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
William A MacDonaldDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Isha MehtaCenter for Systems Immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-6009-0787
Akash KishoreCenter for Systems Immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Augusta VincentCenter for Systems Immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Zhongli XuDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-6843-6212
Anuradha RayDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-6844-8918
Wei ChenDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-7196-8703
Casey T WeaverDepartment of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Bart N LambrechtLaboratory of Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0003-4376-6834
Jishnu DasCenter for Systems Immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-5747-064X
Amanda C PoholekDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. poholeka@pitt.edu.ORCID http://orcid.org/0000-0002-5587-8940
Funding
Lung-specific expression and function of Blimp-1 in T cells impacting allergic asthmaR01AI153104 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POHOLEK, AMANDA CATHERINE · 2021 to 2025
$2.6MDissecting the role of hypoxia in T cell differentiation in cancerR01CA277473 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Greg M. Delgoffe, Yana Najjar · 2023 to 2026
$2.4MUsing three-dimensional protein networks to uncover immuno-modulatory molecular phenotypes in infectious diseaseDP2AI164325 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAS, JISHNU · 2021 to 2025
$2.4MTissue-specific mediators of allergen-driven type 2 inflammationR21AI156093 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POHOLEK, AMANDA CATHERINE · 2021 to 2022
$379kAmerican Lung Association (Lung Association) Innovation AwardNCI NIH HHS R01 CA277473NIAID NIH HHS DP2 AI164325NIAID NIH HHS R01 AI153104NIAID NIH HHS R21 AI156093U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI153104U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI156093U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) DP2AI164325
Abstract
The mechanisms that guide T helper 2 (T
Indexed as
AllergensCell MovementGATA3 Transcription FactorInterleukin-10Interleukin-2LungPositive Regulatory Domain I-Binding Factor 1PyroglyphidaeTh2 CellsAnimalsAsthmaBasic-Leucine Zipper Transcription FactorsCell DifferentiationFemaleLymph NodesMiceAllergensBasic-Leucine Zipper Transcription FactorsBcl6 protein, mouseGata3 protein, mouseGATA3 Transcription FactorIL10 protein, mouseInterleukin-10Interleukin-2Positive Regulatory Domain I-Binding Factor 1Prdm1 protein, mouseProto-Oncogene Proteins c-bcl-6STAT5 Transcription Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.