ArticleHypertension research : official journal of the Japanese Society of Hypertension2025
Home blood pressure stability score is associated with better cardiovascular prognosis: data from the nationwide prospective J-HOP study.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Can intensified activities of the Japanese Society of Hypertension attenuate the seasonal surge in cardiovascular disease? From morning blood pressure and the living environment to seasonally adaptive implementation hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Agreement between seven-day and fourteen-day home systolic blood pressure stability scores: A J-HOP study analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Asian expert consensus on high-quality hypertension management.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- SGLT2 gene polymorphism and cardio-renal outcomes.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Implementation hypertension: a new paradigm for global hypertension control in the JSH 2025, WHO 2025, and AHA/ACC 2025 guideline era.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Engaging the public on World Hypertension Day 2025: "Asakatsu"-Inspired BP screening and educational forum in Hiroshima, Japan.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
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Abstract
A home blood pressure (BP)-centered strategy is emerging as the optimal approach to achieve adequate BP control in individuals with hypertension, but a simple cardiovascular risk score based on home BP level and variability is lacking. This study used prospective data from the Japan Morning Surge-Home Blood Pressure (J-HOP) extended study to develop a simple home BP stability score for the prediction of cardiovascular risk. The J-HOP extended study included 4070 participants (mean age 64.9 years) who measured home BP three times in the morning and evening for 14 days at baseline. During the mean 6.3-year follow-up, there were 260 cardiovascular events. A home BP stability score was calculated based on the average of morning and evening systolic BP (SBP; MEave), and three home BP variability metrics: average real variability (average absolute difference between successive measurements); average peak (average of the highest three SBP values for each individual), and time in therapeutic range (proportion of time spent with MEave home SBP 100-135 mmHg). There was a curvilinear association between the home BP stability score and the risk of cardiovascular events. Compared with individuals in the optimal home SBP stability score group (9-10 points), those in the very high-risk group (0 points) had significantly higher cardiovascular event risk during follow-up (adjusted hazard ratio 3.97, 95% confidence interval 2.22-7.09; p < 0.001), independent of age, sex, medication, cardiovascular risk factors, and office BP. These data show the potential for a simple home BP-based score to predict cardiovascular event risk in people with hypertension.
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