Evidence map›Paper›PMID 39394454›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2025

Epidemiology and treatment of herpes simplex virus in the neonatal intensive care unit.

Nellie Chen, Ryan Kilpatrick, Erik J VerHage, P Brian Smith, Areej Bukhari, Chi D Hornik, Veeral N Tolia, Daniel K Benjamin, Rachel G Greenberg

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nellie ChenDuke University School of Medicine, Durham, NC, USA.
Ryan KilpatrickDivision of Newborn Medicine, Tufts University School of Medicine, Boston, MA, USA.ORCID 0000-0003-1059-2401
Erik J VerHageDepartment of Pediatrics, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-7302-5546
P Brian SmithDepartment of Pediatrics, Duke University Medical Center, Durham, NC, USA.
Areej BukhariDepartment of Pediatrics, Duke University Medical Center, Durham, NC, USA.
Chi D HornikDepartment of Pediatrics, Duke University Medical Center, Durham, NC, USA.
Veeral N ToliaPediatrix Center for Research, Quality, Education and Safety, Sunrise, FL, USA.
Daniel K BenjaminDepartment of Pediatrics, Duke University Medical Center, Durham, NC, USA.
Rachel G GreenbergDepartment of Pediatrics, Duke University Medical Center, Durham, NC, USA. rachel.greenberg@duke.edu.ORCID 0000-0003-4156-8543

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDescribe the epidemiology and clinical characteristics of infants in the neonatal intensive care unit (NICU) with acyclovir exposure and herpes simplex virus (HSV) infection. STUDY

designOur primary analysis was to evaluate the prevalence of HSV infection among infants in the NICU who received acyclovir. We compared characteristics of infants with and without HSV and used multivariable regression analyses to assess associations between infection and clinical outcomes.

resultOf 1,057,061 infants, 17,910 (2%) received acyclovir. Of those who received acyclovir, 1090 (5%) had HSV. Infection was associated with lower gestational age and lower birth weight. Multivariable models demonstrated that infected infants had higher mortality, greater postmenstrual age at discharge, and longer length of stay.

conclusionInfants in the NICU who received acyclovir and have HSV are more likely to be born at lower gestational age, have lower birth weight, and have higher morbidities and mortality.

Indexed as

AcyclovirAntiviral AgentsGestational AgeHerpes SimplexIntensive Care Units, NeonatalBirth WeightFemaleHumansInfant, Low Birth WeightInfant, NewbornInfant, PrematureLength of StayMaleMultivariate AnalysisPrevalenceRetrospective StudiesAcyclovirAntiviral Agents

Identifiers

PMID39394454

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.