Evidence map›Paper›PMID 39394430›Full record

ArticleCommunications biology2024

Type-H endothelial cell protein Clec14a orchestrates osteoblast activity during trabecular bone formation and patterning.

Georgiana Neag, Jonathan Lewis, Jason D Turner, Julia E Manning, Isaac Dean, Melissa Finlay, Gowsihan Poologasundarampillai, Jonathan Woods, Muhammad Arham Sahu, Kabir A Khan and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Georgiana NeagRheumatology Research Group, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0000-0002-3087-867X
Jonathan LewisRheumatology Research Group, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Jason D TurnerRheumatology Research Group, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0000-0002-5423-5302
Julia E ManningRheumatology Research Group, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Isaac DeanSchool of Medical Sciences, University of Birmingham, Birmingham, UK.ORCID 0000-0002-4750-5335
Melissa FinlayRheumatology Research Group, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Gowsihan PoologasundarampillaiSchool of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0000-0002-8498-323X
Jonathan WoodsRheumatology Research Group, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Muhammad Arham SahuRheumatology Research Group, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0000-0003-1043-1819
Kabir A KhanSchool of Medical Sciences, University of Birmingham, Birmingham, UK.
Jenefa BegumRheumatology Research Group, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Helen M McGettrickRheumatology Research Group, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0000-0002-5950-8840
Ilaria BellantuonoHealthy Lifespan Institute, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Victoria HeathSchool of Medical Sciences, University of Birmingham, Birmingham, UK.
Simon W JonesRheumatology Research Group, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0000-0001-6785-2310
Christopher D BuckleyRheumatology Research Group, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Roy BicknellSchool of Medical Sciences, University of Birmingham, Birmingham, UK.
Amy J NaylorRheumatology Research Group, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK. a.naylor@bham.ac.uk.ORCID 0000-0001-8384-8215

Funding

Medical Research Council MR/P016154/1Medical Research Council MR/P021220/1
6 · The paper itself

Abstract

Type-H capillary endothelial cells control bone formation during embryogenesis and postnatal growth but few signalling mechanisms underpinning this influence have been characterised. Here, we identify a highly expressed type-H endothelial cell protein, Clec14a, and explore its role in coordinating osteoblast activity. Expression of Clec14a and its ligand, Mmrn2 are high in murine type-H endothelial cells but absent from osteoblasts. Clec14a

Indexed as

Endothelial CellsLectins, C-TypeOsteoblastsOsteogenesisAnimalsCancellous BoneMiceMice, Inbred C57BLMice, KnockoutLectins, C-Type

Identifiers

PMID39394430
PMCPMC11470016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.