Evidence map›Paper›PMID 39394331›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Deciding treatment end point in necrotizing otitis externa: validation of a standardized clinical response assessment strategy with positron emission tomography findings.

Sindhura Thanneru, Kapil Sikka, Ashu Seith Bhalla, Madhavi Tripathi, Alok Thakar, Anup Singh, Chirom Amit Singh, Hitesh Verma

Abstract readValidation Study
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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sindhura ThanneruAll India Institute of Medical Sciences , New Delhi, India.
Kapil SikkaAll India Institute of Medical Sciences, New Delhi, India. kapil_sikka@yahoo.com.ORCID http://orcid.org/0000-0002-3457-4518
Ashu Seith BhallaDepartment of Radiology, All India Institute of Medical Sciences, New Delhi, India.
Madhavi TripathiDepartment of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
Alok ThakarDepartment of Otorhinolaryngology, All India Institute of Medical Sciences, New Delhi, India.
Anup SinghDepartment of Otorhinolaryngology, All India Institute of Medical Sciences, New Delhi, India.
Chirom Amit SinghDepartment of Otorhinolaryngology, All India Institute of Medical Sciences, New Delhi, India.
Hitesh VermaDepartment of Otorhinolaryngology, All India Institute of Medical Sciences, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPrimary: To explore criteria for treatment endpoint in NOE. Secondary: To study correlation of inflammatory markers, Erythrocyte sedimentation Rate (ESR) and C-reactive protein (CRP) with disease status.

methodsProspective cohort study conducted in a tertiary care hospital over two years (2021-2023) consisted 28 patients with NOE. Treatment culmination point was decided based on symptoms control and correlated with PET-scan findings. Clinical response was analysed with respect to the serum inflammatory markers and PET Scan findings.

resultsThere was fair degree of agreement between clinical resolution and resolution of findings on PET scan (kappa coefficient - 0.76 [95% CI; 0.40,1.00]). Inflammatory markers showed statistically significant decline with clinical resolution but failed to return to normal.

conclusionDecision to terminate treatment of NOE can be reliably made on clinical grounds in patients remaining asymptomatic for three weeks. Resolution of inflammation on PET scan is in congruity with the clinical remission .

Indexed as

Otitis ExternaPositron-Emission TomographyAdultAgedBiomarkersBlood SedimentationC-Reactive ProteinFemaleHumansMaleMiddle AgedNecrosisProspective StudiesBiomarkersC-Reactive Protein18 F-FDG PET/CTCRPESRNecrotizing otitis externa(NOE)Skull Base Osteomyelitis(SBO)Treatment endpoint

Identifiers

PMID39394331

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.