Evidence map›Paper›PMID 39394178›Full record

ArticleNature communications2024

Direct recognition of an intact foreign protein by an αβ T cell receptor.

Catarina F Almeida, Benjamin S Gully, Claerwen M Jones, Lukasz Kedzierski, Sachith D Gunasinghe, Michael T Rice, Richard Berry, Nicholas A Gherardin, Trang T Nguyen, Yee-Foong Mok and 7 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Catarina F Almeida *Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.ORCID 0000-0002-3393-4411
Benjamin S Gully *Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0002-8197-0871
Claerwen M JonesInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0001-8594-9554
Lukasz KedzierskiInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0003-0203-1057
Sachith D GunasingheInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0003-3794-3005
Michael T RiceInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0002-2693-0252
Richard BerryInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0001-7043-0469
Nicholas A GherardinDepartment of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.ORCID 0000-0003-4690-2571
Trang T NguyenInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Yee-Foong MokMelbourne Protein Characterisation Platform, Bio21 Molecular Science and Biotechnology Institute, Melbourne, VIC, Australia.
Josephine F ReijneveldDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8695-964X
D Branch MoodyDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2306-3058
Ildiko Van RhijnDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1446-5701
Nicole L La GrutaInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0001-5358-9363
Adam P UldrichDepartment of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia. auldrich@unimelb.edu.au.ORCID 0000-0002-6350-5976
Jamie RossjohnInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. Jamie.rossjohn@monash.edu.ORCID 0000-0002-2020-7522
Dale I GodfreyDepartment of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia. godfrey@unimelb.edu.au.ORCID 0000-0002-3009-5472

Funding

CD1 autoreactive T cells in human inflammatory skin diseaseR37AR048632 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI DAVID Branch MOODY · 2025 to 2026
$1.1M
Anxiety With Cancer in the Elderly (ACE): A Cognitive-Behavioral InterventionK23AG048632 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI MCCONNELL, KELLY · 2014 to 2018
$782k
NIAMS NIH HHS R37 AR048632NIA NIH HHS K23 AG048632
6 · The paper itself

Abstract

αβ T cell receptors (αβTCRs) co-recognise antigens when bound to Major Histocompatibility Complex (MHC) or MHC class I-like molecules. Additionally, some αβTCRs can bind non-MHC molecules, but how much intact antigen reactivities are achieved remains unknown. Here, we identify an αβ T cell clone that directly recognises the intact foreign protein, R-phycoerythrin (PE), a multimeric (αβ)

Indexed as

Receptors, Antigen, T-Cell, alpha-betaAnimalsComplementarity Determining RegionsCrystallography, X-RayHumansLymphocyte ActivationMiceMice, Inbred C57BLModels, MolecularPhycoerythrinProtein BindingT-LymphocytesComplementarity Determining RegionsPhycoerythrinReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID39394178
PMCPMC11470135

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.