Evidence map›Paper›PMID 39394033›Full record

ArticleInternational dental journal2025

Anti-Radiofibrosis Effect of Dicliptera chinensis Polysaccharide on Rat Dermal Fibroblasts Via The TGF-β1/Smads/CTGF Signaling Pathway.

Yude Huang, Lixiang Zhao, Yanfei Zhao, Yiyang Fan, Linjing Gao, Haoyu Lu, Xian Wang, Dongqin Mo, Daiyou Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International dental journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Research on the mechanisms of natural products in radiation protection.Frontiers in bioengineering and biotechnology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yude HuangCollege of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China; Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Nanning, China; Guangxi Clinical Medical Research Center for craniofacial Deformity, Nanning, China.
Lixiang ZhaoCollege of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China; Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Nanning, China; Guangxi Clinical Medical Research Center for craniofacial Deformity, Nanning, China.
Yanfei ZhaoCollege of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China; Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Nanning, China; Guangxi Clinical Medical Research Center for craniofacial Deformity, Nanning, China.
Yiyang FanCollege of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China; Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Nanning, China; Guangxi Clinical Medical Research Center for craniofacial Deformity, Nanning, China.
Linjing GaoCollege of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China; Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Nanning, China; Guangxi Clinical Medical Research Center for craniofacial Deformity, Nanning, China.
Haoyu LuCollege of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China; Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Nanning, China; Guangxi Clinical Medical Research Center for craniofacial Deformity, Nanning, China.
Xian WangCollege of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China; Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Nanning, China; Guangxi Clinical Medical Research Center for craniofacial Deformity, Nanning, China.
Dongqin MoCollege of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China; Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Nanning, China; Guangxi Clinical Medical Research Center for craniofacial Deformity, Nanning, China.
Daiyou WangCollege of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China. Electronic address: wangdaiyou@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRadiotherapy is an effective treatment for head and neck cancer; however, irradiated normal tissues are inevitably damaged, resulting in skin radioactive fibrosis. Dicliptera chinensis polysaccharide (DCP), the primary active compound extracted from the natural medicinal Dicliptera chinensis, exhibits antioxidant, anti-inflammatory, and anti-radiation properties. In this study, we investigated the protective effects of DCP against radioactive fibrosis in rat dermal fibroblasts (RDF) and explored the underlying mechanisms involved.

designRDFs were treated with DCP, and the CCK8 assay was used to determine cellular activity. The rates of apoptosis and cell cycle progression were detected using flow cytometry. mRNA expression levels were quantified using real-time polymerase chain reaction. Protein levels were analysed through Western blotting and immunofluorescence staining

resultsDCP reduced radiation-induced apoptosis, and the cell cycle G2/M arrest was alleviated. Furthermore, DCP decreased the expression of key fibrosis-related markers, including α-SMA, TGF-β1, Smad3, and CTGF.

conclusionDCP exhibits a protective effect against radiation-induced fibrosis.

Indexed as

Connective Tissue Growth FactorFibroblastsPolysaccharidesSkinSmad ProteinsTransforming Growth Factor beta1AnimalsApoptosisBlotting, WesternCells, CulturedFibrosisFlow CytometryRatsReal-Time Polymerase Chain ReactionSignal TransductionSmad3 ProteinCCN2 protein, ratConnective Tissue Growth FactorPolysaccharidesSmad3 ProteinSmad3 protein, ratSmad ProteinsTransforming Growth Factor beta1apoptosisDicliptera chinensis polysaccharideRadiofibrosisTGF-β1/Smads/CTGF signalling pathway

Identifiers

PMID39394033
PMCPMC11976618

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.