Evidence map›Paper›PMID 39393643›Full record

ArticleBiochemical pharmacology2024

Non-additivity of the functional properties of individual P450 species and its manifestation in the effects of alcohol consumption on the metabolism of ketamine and amitriptyline.

Kannapiran Ponraj, Kari A Gaither, Dilip Kumar Singh, Nadezhda Davydova, Mengqi Zhao, Shaman Luo, Phillip Lazarus, Bhagwat Prasad, Dmitri R Davydov

Abstract read
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In one paragraph

Article in Biochemical pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kannapiran PonrajDepartment of Chemistry, Washington State University, Pullman, WA 99164, USA.
Kari A GaitherDepartment of Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.
Dilip Kumar SinghDepartment of Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.
Nadezhda DavydovaDepartment of Chemistry, Washington State University, Pullman, WA 99164, USA.
Mengqi ZhaoDepartment of Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.
Shaman LuoDepartment of Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.
Phillip LazarusDepartment of Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.
Bhagwat PrasadDepartment of Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.
Dmitri R DavydovDepartment of Chemistry, Washington State University, Pullman, WA 99164, USA. Electronic address: d.davydov@wsu.edu.

Funding

Inter-Enzyme Crosstalk in the Cytochrome P450 Ensemble: Implications for the Effects of Alcohol on Drug Metabolism and Alcohol-Drug InteractionsR01AA030155 · NIAAA · WASHINGTON STATE UNIVERSITY · PI DAVYDOV, DMITRI R, PRASAD, BHAGWAT · 2022 to 2025
$2.0M
NIAAA NIH HHS R01 AA030155
6 · The paper itself

Abstract

To explore functional interconnections between multiple P450 enzymes and their manifestation in alcohol-induced changes in drug metabolism, we implemented a high-throughput study of correlations between the composition of the P450 pool and the substrate saturation profiles (SSP) of amitriptyline and ketamine demethylation in a series of 23 individual human liver microsomes preparations from donors with a known history of alcohol consumption. The SSPs were approximated with linear combinations of three Michaelis-Menten equations with globally optimized K

Indexed as

Alcohol DrinkingAmitriptylineCytochrome P-450 Enzyme SystemKetamineMicrosomes, LiverAdultFemaleHumansMaleAmitriptylineCytochrome P-450 Enzyme SystemKetamineAlcohol exposureAmitriptylinecytochrome P450Drug metabolismHuman liver microsomesKetamineProportional projection

Identifiers

PMID39393643
PMCPMC11609013

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.