Evidence map›Paper›PMID 39393311›Full record

ArticleBiochemical and biophysical research communications2024

AMP dependent protein kinase regulates endothelial heparan sulfate expression in response to an inflammatory stimulus under arterial shear stress.

Rick Mathews, Jiaqing Pang, Siddharth A Muralidaran, Caitlin G X King, Owen J T McCarty, Monica T Hinds

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rick MathewsDepartment of Biomedical Engineering, Oregon Health & Science University, 3303 S Bond Avenue CH13B, Portland, OR, 97239, USA. Electronic address: mathewri@ohsu.edu.
Jiaqing PangDepartment of Biomedical Engineering, Oregon Health & Science University, 3303 S Bond Avenue CH13B, Portland, OR, 97239, USA. Electronic address: pangj@ohsu.edu.
Siddharth A MuralidaranDepartment of Biomedical Engineering, Oregon Health & Science University, 3303 S Bond Avenue CH13B, Portland, OR, 97239, USA. Electronic address: siddharth.muralidaran@gmail.com.
Caitlin G X KingDepartment of Biomedical Engineering, University of Wisconsin-Madison, 1550 Engineering Dr, Madison, WI, 53706, USA. Electronic address: cgking3@wisc.edu.
Owen J T McCartyDepartment of Biomedical Engineering, Oregon Health & Science University, 3303 S Bond Avenue CH13B, Portland, OR, 97239, USA. Electronic address: mccartyo@ohsu.edu.
Monica T HindsDepartment of Biomedical Engineering, Oregon Health & Science University, 3303 S Bond Avenue CH13B, Portland, OR, 97239, USA. Electronic address: hindsm@ohsu.edu.

Funding

Engineering of biomaterials with controlled biomolecule delivery for cardiovascular applicationsR01HL168868 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Monica T Hinds · 2024 to 2026
$1.9M
Role of glycosaminoglycans (GAGs) in deep vein thrombus formation and resolutionF30HL163918 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI MATHEWS, RICK · 2022 to 2025
$213k
NHLBI NIH HHS F30 HL163918NHLBI NIH HHS R01 HL168868
6 · The paper itself

Abstract

Heparan sulfate (HS) is the most abundant glycosaminoglycan on the vascular endothelium and can regulate endothelial cell morphology and function in response to mechanical stimuli. This study investigated endothelial HS response to an inflammatory stimulus under static and arterial shear stress conditions. Human aortic endothelial cells (HAECs) under static conditions expressed significantly higher HS when treated with an inflammatory stimulus compared to untreated controls. HAECs exposed to an inflammatory stimulus after being conditioned with 10 dyn/cm

Indexed as

AMP-Activated Protein KinasesEndothelial CellsHeparan SulfateInflammationStress, MechanicalAortaArteriesCells, CulturedEndothelium, VascularHumansShear StrengthAMP-Activated Protein KinasesHeparan SulfateAMPKEndothelialFlowGlycocalyxHeparan sulfateInflammationKinaseStaticTNFa

Identifiers

PMID39393311
PMCPMC11601061

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.