Evidence map›Paper›PMID 39393277›Full record

ArticleClinics (Sao Paulo, Brazil)2024

Improvement of motor function in mice after implantation of mononuclear stem cells from human umbilical cord and placenta blood after 3 and 6 weeks of experimental spinal cord injury.

Thiego Pedro Freitas Araujo, Alexandre Fogaça Cristante, Raphael Martus Marcon, Gustavo Bispo Dos Santos, Maria Helena Alves Nicola, Alex Oliveira de Araujo, Fernando Barbosa Sanchez, Tarcísio Eloy Pessoa de Barros Filho

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Article in Clinics (Sao Paulo, Brazil), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Thiego Pedro Freitas AraujoDepartment of Orthopedic Surgery, Hospital Sírio Libanês, Brasília, DF, Brazil. Electronic address: thiegopedro@gmail.com.
Alexandre Fogaça CristanteDepartment of Orthopedic Surgery, Instituto de Ortopedia e Traumatologia da Universidade de São Paulo, São Paulo, SP, Brazil.
Raphael Martus MarconDepartment of Orthopedic Surgery, Instituto de Ortopedia e Traumatologia da Universidade de São Paulo, São Paulo, SP, Brazil.
Gustavo Bispo Dos SantosDepartment of Orthopedic Surgery, Instituto de Ortopedia e Traumatologia da Universidade de São Paulo, São Paulo, SP, Brazil.
Maria Helena Alves NicolaCryopraxis Cryobiology, Espírito Santo do Pinhal, SP, Brazil.
Alex Oliveira de AraujoDepartment of Orthopedic Surgery, Rede SARAH de Hospitais de Reabilitação, SMHS - Área Especial, Brasília, DF, Brazil.
Fernando Barbosa SanchezDepartment of Orthopedic Surgery, Instituto de Ortopedia e Traumatologia da Universidade de São Paulo, São Paulo, SP, Brazil.
Tarcísio Eloy Pessoa de Barros FilhoDepartment of Orthopedic Surgery, Instituto de Ortopedia e Traumatologia da Universidade de São Paulo, São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designExperimental study utilizing with a standardized model (MASCIS Impactor) of Spinal Cord Injury (SCI) in Balb C mouse model with implantation of mononuclear stem cells derived from the human umbilical cord and placenta blood in the early chronic phase of SCI.

objectivesThe aim of this study was to evaluate the nerve regeneration and motor functional recovery in Balb C mice with surgically induced paraplegia in response to the use of mononuclear stem cells, in early chronic phase (> 2 weeks and < 6 months), because there is yet potential of neuronal and functional recovery as the neuronal scar is not still completely established.

methodsForty-eight mice were randomly assigned to 6 groups of 8 animals. Group 1 received the stem cells 3 weeks after the trauma, and Group 2 received them six weeks later. In Group 3, saline solution was injected at the site of the lesion 3 weeks after the trauma, and in Group 4, 6 weeks later. Group 5 underwent only spinal cord injury and Group 6 underwent laminectomy only. The scales used for motor assessment were BMS and MFS for 12 weeks.

resultsThe intervention groups showed statistically significant motor improvement. In the histopathological analysis, the intervention groups had a lower degree of injury (p < 0.05). Regarding axonal budding, the intervention groups showed increasing in axonal budding in the caudal portion (p < 0.05).

conclusionsThe use of stem cells in mice in the chronic phase after 3 and 6 weeks of SCI brings functional and histopathological benefits to them.

Indexed as

Cord Blood Stem Cell TransplantationMesenchymal Stem CellsMotor SkillsSpinal Cord InjuriesAnimalsAxon FasciculationFetal BloodMaleMiceMice, Inbred BALB CNerve Fibers, MyelinatedPlacentaUmbilical CordHistopathological evaluationMesenchymal stem cellsMotor evaluationSpinal cord traumaUmbilical cord

Identifiers

PMID39393277
PMCPMC11736333

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