ArticleJMIR research protocols2024
A Comparison of Conventional Root Canal Sealers With Ones That Use Green Synthesized Nanoparticles for Antimicrobial Activity: Protocol for a Systematic Review.
Article in JMIR research protocols, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- The Fracture Resistance of Endodontically Treated Teeth Restored Using 3 Different Posts: Protocol for a Comparative Evaluation Study.JMIR research protocols · 2026Article
- Evaluation of the Antimicrobial Efficacy of Cerium Oxide Nanoparticles and Chlorhexidine Gluconate Against Enterococcus faecalis in Root Canal Systems: Protocol for an In Vitro Study.JMIR research protocols · 2026Article
- Enhancing Fracture Resistance by Customizing Glass Fiber Posts in Endodontically Treated Teeth: Protocol for a Systematic Review.JMIR research protocols · 2026Article
- Comparative Evaluation of Push-Out Bond Strength of Glass Fiber Posts and Carbon Fiber Posts in Root Canals Treated With Calcium Hydroxide-Based, Resin-Based, and Bioceramic-Based Root Canal Sealers: Protocol for an In Vitro Study.JMIR research protocols · 2026Article
- Comparative Evaluation of the Antibacterial Efficacy of Metronidazole, Chlorhexidine, and Normal Saline as Laser- and Sonic-Activated Intracanal Irrigants AgainstJMIR research protocols · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRoot canal failure and secondary endodontic infection are frequent clinical scenarios in dentistry. The main microorganisms implicated in root canal therapy failure are persistent Enterococcus faecalis, Candida albicans, and Staphylococcus aureus. To combat the impact of disease resistance, scientists are concentrating on alternative antimicrobial root canal sealers. Nanomaterials are a recent development in endodontic materials that exhibit great antimicrobial properties, making them an ideal material choice for root canal sealers.
objectiveThis systematic review aims to compare the antimicrobial properties of conventional root canal sealers to those incorporating green synthesized nanoparticles between 2010 and 2024.
methodsA well-constructed protocol was established and registered with PROSPERO (CRD42021286373). Ethics approval was obtained from the Biomedical Research and Ethics Committee from the University of the Western Cape (UWC; BM22/1/4). PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) reporting guidelines were followed. The included criteria demonstrate the green synthesized nanoparticles studies where the nanoparticles (NPs) are incorporated in root canal sealers. MeSH (Medical Subject Headings) terms were used for the search strategy of the systematic electronic databases for articles published in English between 2010 and 2024. The selected databases included Scopus, PubMed, Web of Science, Science Direct, EBSCOhost, SpringerLink, and Wiley Online. A quality assessment tool for laboratory studies will be used to critically appraise the included studies. If applicable, statistical measures (mean, SD, etc) will be used for data analysis and presentation of the results.
resultsThe protocol is registered with PROSPERO. A preliminary search was conducted using a determined search strategy across 8 electronic databases, and the review is now complete.
conclusionsIt is anticipated that the results of this systematic review may reveal the increased interest and application for nanoparticle-enhanced root canal sealers. This will aid in the future development of root canal sealants and mitigate the risk of endodontic failure.
trial registrationPROSPERO CRD42021286373; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=286373. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/51351.
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