ArticleNeurology(R) neuroimmunology & neuroinflammation2024
Cognitive Impairment, Associated Clinical Factors, and MR Volumetric Measures in Myelin Oligodendrocyte Glycoprotein-IgG-Associated Disease.
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Article in Neurology(R) neuroimmunology & neuroinflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Frequent early cognitive impairment in both pediatric MS and MOGAD.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.Annals of clinical and translational neurology · 2026Article
- Comparison of Three Automated Measurements of Ventricular Volumes of the Brain.Journal of imaging informatics in medicine · 2026Article
- Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: Pathophysiology, Clinical Patterns, and Therapeutic Challenges of Intractable and Severe Forms.International journal of molecular sciences · 2025Review
- Cognitive Outcomes in Myelin Oligodendrocyte Glycoprotein-IgG Associated Disease Compared to Multiple Sclerosis.Brain and behavior · 2025Article
- Ten Years ofNeurology(R) neuroimmunology & neuroinflammation · 2025Article
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17 authors.
Ann-Kathrin KogelFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.ORCID 0000-0002-8217-6063
Theodoros LadopoulosFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.
Carolin SchwakeFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.
Ingo KleiterFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.ORCID 0000-0002-8249-4408
Bianca TeegenFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.
Nadine SiemsFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.
Christian PrehnFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.
Solveig LichtenbergFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.
Marius RingelsteinFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.ORCID 0000-0003-3618-8407
Orhan AktasFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.ORCID 0000-0002-2020-9210
Refik PulFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.ORCID 0000-0002-8940-9317
Britta KriegerFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.
Carsten LukasFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.ORCID 0000-0002-8562-9697
Iris-Katharina PennerFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.
Ralf GoldFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.ORCID 0000-0002-7223-3052
Ruth SchneiderFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.ORCID 0000-0002-0997-2725
Ilya AyzenbergFrom the Department of Neurology (A.-K.K., T.L., C.S., N.S., C.P., S.L., R.G., R.S., I.A.); Institute of Neuroradiology (T.L., B.K., C.L., R.S.), St Josef Hospital, Ruhr University Bochum; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Euroimmun Reference Laboratory (B.T.), Lübeck; Department of Neurology (M.R., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Center for Translational Neuro- and Behavioral Sciences (R.P.), University Medicine Essen, University of Duisburg-Essen, Germany; Department of Neurology (I.-K.P.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.-K.P.), Düsseldorf, Germany.ORCID 0009-0007-9491-2180
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesCognitive impairment is a common and challenging symptom in multiple sclerosis and neuromyelitis optica spectrum disease; however, data in myelin oligodendrocyte glycoprotein-IgG-associated disease (MOGAD) remain scarce. In this cross-sectional study, we investigated the frequency of cognitive impairment, associated clinical factors, and MRI volumetric measures in MOGAD.
methodsParticipants were investigated in a single center by certified psychologists and underwent a standardized 3-T-MRI protocol. MRI data were processed with FreeSurfer for gray and white matter volume estimation, presented as a fraction of total intracranial volume. Sera screening for antineural antibodies has been conducted using cell-based assays. The following clinical factors were included in the multivariate logistic regression analysis: sex, age, overall number of previous relapses, and specifically the history of acute disseminated encephalomyelitis (ADEM)/ADEM-like episodes and other brain relapses.
resultsThirty-two patients with MOGAD (19 female, median age 29.4 years) after a median of 2 relapses with a median EDSS of 1.0 were recruited. Seven patients (21.9%) demonstrated cognitive impairment with the most prevalent deficits in mental flexibility (16.7%), attention (11.1%-14.8%), and verbal working memory (10.3%). 72.4% suffered from fatigue and 42.9% from signs of depression, moderate to severe in 28.6%. The overall number of previous relapses (odds ratio [OR] 1.789, 95% CI 1.041-3.074) and specifically ADEM/ADEM-like episodes (OR 16.929, 95% CI 1.228-233.427) were the only clinical factors associated with cognitive impairment in a multivariate logistic regression model. Screening for antineuronal antibodies remained negative. Cerebral white matter (WM) (0.300 vs 0.317, DISCUSSION: Despite a low overall disability, every 5th patient with MOGAD experiences cognitive impairment. Cognitive impairment is associated with a higher number of relapses and particularly ADEM/ADEM-like attacks. Although both WM and DGM atrophies are apparent in MOGAD, the latter only seems to have an association with cognitive impairment.
Indexed as
Cognitive DysfunctionMagnetic Resonance ImagingMyelin-Oligodendrocyte GlycoproteinAdolescentAdultAutoantibodiesCross-Sectional StudiesFemaleHumansImmunoglobulin GMaleMiddle AgedYoung AdultAutoantibodiesImmunoglobulin GMOG protein, humanMyelin-Oligodendrocyte Glycoprotein
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