Evidence map›Paper›PMID 39392867›Full record

ArticleeLife2024

Heterozygous expression of a

Amy N Shore, Keyong Li, Mona Safari, Alshaima'a M Qunies, Brittany D Spitznagel, C David Weaver, Kyle Emmitte, Wayne Frankel, Matthew C Weston

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Amy N ShoreFralin Biomedical Research Institute at Virginia Tech Carilion, Center for Neurobiology Research, Roanoke, United States.
Keyong LiFralin Biomedical Research Institute at Virginia Tech Carilion, Center for Neurobiology Research, Roanoke, United States.
Mona SafariFralin Biomedical Research Institute at Virginia Tech Carilion, Center for Neurobiology Research, Roanoke, United States.
Alshaima'a M QuniesDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, United States.
Brittany D SpitznagelDepartment of Pharmacology, Vanderbilt University, Nashville, United States.
C David WeaverDepartment of Pharmacology, Vanderbilt University, Nashville, United States.
Kyle EmmitteDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, United States.
Wayne FrankelInstitute for Genomic Medicine, Columbia University, New York, United States.ORCID https://orcid.org/0000-0003-2241-5314
Matthew C WestonFralin Biomedical Research Institute at Virginia Tech Carilion, Center for Neurobiology Research, Roanoke, United States.ORCID https://orcid.org/0000-0001-5558-7070

Funding

GENETIC DETERMINANTS OF EPILEPSY IN MURINE SYSTEMSR01NS031348 · NINDS · JACKSON LABORATORY · PI SANDS, TRISTAN T · 1993 to 2025
$11.5M
The Jackson Laboratory Center for Precision Genetics: From New Models to Novel TherapeuticsU54OD020351 · OD · JACKSON LABORATORY · PI LUTZ, CATHLEEN M · 2015 to 2019
$10.2M
Synaptic changes and hypersynchronous network activity in mTORopathiesR01NS110945 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WESTON, MATTHEW C · 2019 to 2023
$1.7M
Cell Type-Specific Roles of the Na-Activated K Current in KCNT1-Related EpilepsyR01NS130042 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Matthew C Weston · 2023 to 2026
$1.6M
Slack Potassium Channel Inhibitors for the Treatment of Childhood EpilepsiesR33NS109521 · NINDS · VANDERBILT UNIVERSITY · PI EMMITTE, KYLE A, WEAVER, C DAVID · 2020 to 2021
$787k
KINDLING ANTAGONISM: A MODEL FOR SEIZURE PROPAGATIONR01NS020351 · NINDS · UNIVERSITY OF ROCHESTER · PI BURCHFIEL, JAMES L · 1985 to 1995
–
NIH HHS U54 OD020351NIH/NINDS R01NS031348NIH/NINDS R01NS130042NIH/NINDS R33NS109521NIH/NINDS U54OD020351NINDS NIH HHS R01 NS031348NINDS NIH HHS R01 NS110945NINDS NIH HHS R01 NS130042NINDS NIH HHS R33 NS109521
6 · The paper itself

Abstract

More than 20 recurrent missense gain-of-function (GOF) mutations have been identified in the sodium-activated potassium (K

Indexed as

GABAergic NeuronsGain of Function MutationParvalbuminsSomatostatinAction PotentialsAnimalsCerebral CortexFemaleHeterozygoteMaleMiceMutation, MissensePotassium Channels, Voltage-GatedParvalbuminsPotassium Channels, Voltage-GatedSomatostatinaction potentialcortexepilepsyinterneuronKCNT1modelingmolecular biophysicsmouseneurosciencestructural biology

Identifiers

PMID39392867
PMCPMC11469685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.