Evidence map›Paper›PMID 39392790›Full record

ArticlePloS one2024

DR-GPT: A large language model for medical report analysis of diabetic retinopathy patients.

Joel Jaskari, Jaakko Sahlsten, Paula Summanen, Jukka Moilanen, Erika Lehtola, Marjo Aho, Elina Säpyskä, Kustaa Hietala, Kimmo Kaski

Abstract read
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Joel JaskariDepartment of Computer Science, Aalto University, Espoo, Finland.ORCID 0000-0002-6154-2378
Jaakko SahlstenDepartment of Computer Science, Aalto University, Espoo, Finland.ORCID 0000-0002-7364-6502
Paula SummanenDepartment of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-0028-5056
Jukka MoilanenDepartment of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Erika LehtolaDepartment of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Marjo AhoDepartment of Ophthalmology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Elina SäpyskäDepartment of Ophthalmology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Kustaa HietalaCentral Finland Health Care District, Jyväskylä, Finland.
Kimmo KaskiDepartment of Computer Science, Aalto University, Espoo, Finland.ORCID 0000-0002-3805-9687

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic retinopathy (DR) is a sight-threatening condition caused by diabetes. Screening programmes for DR include eye examinations, where the patient's fundi are photographed, and the findings, including DR severity, are recorded in the medical report. However, statistical analyses based on DR severity require structured labels that calls for laborious manual annotation process if the report format is unstructured. In this work, we propose a large language model DR-GPT for classification of the DR severity from unstructured medical reports. On a clinical set of medical reports, DR-GPT reaches 0.975 quadratic weighted Cohen's kappa using truncated Early Treatment Diabetic Retinopathy Study scale. When DR-GPT annotations for unlabeled data are paired with corresponding fundus images, the additional data improves image classifier performance with statistical significance. Our analysis shows that large language models can be applied for unstructured medical report databases to classify diabetic retinopathy with a variety of applications.

Indexed as

Diabetic RetinopathyHumansSeverity of Illness Index

Identifiers

PMID39392790
PMCPMC11469499

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.