Prognostic role of serum copeptin levels in adults with graded traumatic brain injury.

Olgun Demir, Adem Az, Sumeyye Cakmak, Ozgur Sogut

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Article in Irish journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Olgun DemirDepartment of Emergency Medicine, University of Health Sciences, Haseki Training and Research Hospital, Ugur Mumcu, Atatürk Street 54, 34265, Sultangazi, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-7792-8320

Adem AzDepartment of Emergency Medicine, University of Health Sciences, Haseki Training and Research Hospital, Ugur Mumcu, Atatürk Street 54, 34265, Sultangazi, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-7204-6185

Sumeyye CakmakDepartment of Emergency Medicine, University of Health Sciences, Haseki Training and Research Hospital, Ugur Mumcu, Atatürk Street 54, 34265, Sultangazi, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-9573-8611

Ozgur SogutDepartment of Emergency Medicine, University of Health Sciences, Haseki Training and Research Hospital, Ugur Mumcu, Atatürk Street 54, 34265, Sultangazi, Istanbul, Turkey. ozgur.sogut@sbu.edu.tr.ORCID http://orcid.org/0000-0003-3365-3713

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6 · The paper itself

Abstract

backgroundThe efficacy of copeptin in patients with severe head injuries remains unclear.

aimsTo investigate the role of serum copeptin levels in detecting intracranial injury, assessing trauma severity, and predicting outcomes in adults with graded traumatic brain injury (TBI).

methodsThis prospective non-randomized controlled study enrolled 78 adults with isolated head trauma, as well as 59 age- and sex-matched controls. Baseline serum copeptin levels were measured in both groups. Patients were categorized by head trauma severity using Glasgow Coma Scale (GCS) scores (severe GCS 3-8, moderate GCS 9-13, mild GCS 14-15) and by the presence of intracerebral or extracerebral lesions on cranial computed tomography (CCT). Patients were also classified as survivors or non-survivors. Serum copeptin levels were compared among these.

resultsMean serum copeptin levels were significantly higher in patients with graded TBI than in controls. Furthermore, patients with severe and moderate head trauma had significantly higher copeptin levels compared with patients exhibiting mild trauma. An optimal copeptin cutoff value of > 1147 pg/mL was identified, indicating the presence of moderate or severe trauma in TBI patients. Patients with abnormal CCT findings had significantly higher mean serum copeptin levels compared with patients exhibiting normal CCT scans. Non-survivors also showed significantly higher serum copeptin levels compared with survivors.

conclusionSerum copeptin levels rise after graded TBI and can distinguish between patients with and without intracranial or extracranial lesions evident on CCT. Copeptin levels also aid in identifying moderate or severe TBI and in predicting 28-day mortality.

Indexed as

Brain Injuries, TraumaticGlycopeptidesAdultAgedBiomarkersCase-Control StudiesFemaleGlasgow Coma ScaleHumansMaleMiddle AgedPrognosisProspective StudiesTomography, X-Ray ComputedBiomarkerscopeptinsGlycopeptidesCopeptinCranial computed tomographyInjury severityMortalityTraumatic brain injury

Identifiers

PMID39392564

DOI10.1007/s11845-024-03818-y

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.