Evidence map›Paper›PMID 39392546›Full record

Trial reportPrevention science : the official journal of the Society for Prevention Research2025

Fast Track Intervention Effects and Mechanisms of Action Through Established Adulthood.

George McCabe, Jennifer W Godwin, W Andrew Rothenberg, Natalie Goulter, Jennifer E Lansford, Conduct Problems Prevention Research Group

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Prevention science : the official journal of the Society for Prevention Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01653535 (Multisite Prevention of Conduct Problems), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01653535 naactive not recruitingnot on this map

Multisite Prevention of Conduct Problems

TypeinterventionalSponsorDuke UniversityRan1991 to 2029Enrolled891ConditionsConduct Disorder, Anti-Social BehaviorArmsFast Track
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Annual Research Review: Beyond the target - understanding crossover effects in family-centered prevention.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Review
  3. Article
  4. Introduction to the Special Issue: Prevention Science and Youth Conduct Problems: Development, Prevention, and Treatment.Prevention science : the official journal of the Society for Prevention Research · 2025
    Article
  5. Honoring the Work of Robert McMahon: a Commentary on This Special Issue.Prevention science : the official journal of the Society for Prevention Research · 2025
    Article
  6. The Multiple Avenues of Contribution of Robert McMahon to Prevention Science.Prevention science : the official journal of the Society for Prevention Research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

George McCabeDuke University, Center for Child and Family Policy, Durham, USA.
Jennifer W GodwinDuke University, Center for Child and Family Policy, Durham, USA.
W Andrew RothenbergDuke University, Center for Child and Family Policy, Durham, USA.
Natalie GoulterFlinders University, College of Education, Psychology, & Social Work, Flinders Institute for Mental Health & Wellbeing, Adelaide, Australia. natalie.goulter@flinders.edu.au.ORCID 0000-0003-0682-7781
Jennifer E LansfordDuke University, Center for Child and Family Policy, Durham, USA.
Conduct Problems Prevention Research Group

Funding

TRANSLATION AND DISSEMINATION COREP30DA023026 · NIDA · DUKE UNIVERSITY · PI HOYLE, RICK · 2008 to 2023
$19.6M
Optimizing Prevention of Costly Adult OutcomesR01DA016903 · NIDA · DUKE UNIVERSITY · PI CROWLEY, DANIEL MAX, DODGE, KENNETH A · 2003 to 2019
$10.2M
Vulnerability to Drug Abuse:Pathways to RecoveryR01DA011301 · NIDA · DUKE UNIVERSITY · PI COSTELLO, ELIZABETH JANE · 1997 to 2015
$7.3M
Intervention Impacts on Child Wellbeing and Parenting across GenerationsR01HD093651 · NICHD · DUKE UNIVERSITY · PI KENNETH A DODGE, Jennifer E Lansford · 2017 to 2026
$6.1M
MULTISITE PREVENTION OF CONDUCT PROBLEMSR18MH048043 · NIMH · DUKE UNIVERSITY · PI DODGE, KENNETH A · 1990 to 2002
$5.8M
Science CoreP2CHD065563 · NICHD · DUKE UNIVERSITY · PI Giovanna M Merli · 2015 to 2026
$5.7M
MULTISITE PREVENTION OF CONDUCT DISORDERSR18MH050951 · NIMH · UNIVERSITY OF WASHINGTON · PI MCMAHON, ROBERT J. · 1993 to 2002
$3.7M
MULTISITE PREVENTION OF CONDUCT DISORDERR18MH050952 · NIMH · VANDERBILT UNIVERSITY · PI PINDERHUGHES, ELLEN E · 1993 to 2002
$3.7M
MULTISITE PREVENTION OF CONDUCT DISORDERR18MH050953 · NIMH · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI BIERMAN, KAREN L · 1993 to 2002
$3.5M
ECONOMIC ANALYSIS OF THE FAST TRACK INTERVENTIONR01MH062988 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FOSTER, EDWARD MICHAEL · 2002 to 2007
$2.8M
Diseases of Despair in Young Adulthood: Risk, Resilience, and PreventionR01MH117559 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI COPELAND, WILLIAM · 2018 to 2021
$1.6M
Adolescent Drug Use: Development, Prevention, and PolicyK05DA015226 · NIDA · DUKE UNIVERSITY · PI DODGE, KENNETH A · 2002 to 2012
$1.2M
Department of Education S184U30002NICHD NIH HHS P2C HD065563NICHD NIH HHS R01 HD093651NIDA NIH HHS K05 DA015226NIDA NIH HHS K05 DA15226NIDA NIH HHS P30 DA023026NIDA NIH HHS R01 DA011301NIDA NIH HHS R01 DA016903NIDA NIH HHS R01 DA036523NIDA NIH HHS R01 DA11301NIDA NIH HHS RC1 DA028248NIMH NIH HHS K05 MH000797NIMH NIH HHS K05 MH001027NIMH NIH HHS K05 MH00797NIMH NIH HHS K05 MH01027NIMH NIH HHS R01 MH062988NIMH NIH HHS R01 MH117559NIMH NIH HHS R18 MH048043NIMH NIH HHS R18 MH050951NIMH NIH HHS R18 MH050952NIMH NIH HHS R18 MH050953NIMH NIH HHS R18 MH48043NIMH NIH HHS R18 MH50951NIMH NIH HHS R18 MH50952NIMH NIH HHS R18 MH50953
6 · The paper itself

Abstract

Early preventive interventions can improve outcomes in childhood, but the most effective interventions can continue to deliver benefits through the life course. The Fast Track intervention, a randomized controlled trial for children at risk of conduct problems, has lowered psychopathology, substance use problems, and criminality and elevated happiness at age 25. However, research has not studied whether the intervention's effects continue further into established adulthood. In addition, little is known about the mechanisms through which the intervention may affect adult outcomes. We attempted to answer both questions by simultaneously estimating the intervention's direct effect on adult outcomes at age 31 and the intervention's indirect effects on those outcomes via interpersonal, intrapersonal, and academic competencies gained through the intervention. Participants included the Fast Track intervention (n = 445; 72.4% male) and high-risk control samples (n = 446; 66.4% male). Direct and total effects of random assignment to Fast Track on age 31 outcomes were not significant. However, our analyses showed that Fast Track's improvements to interpersonal and intrapersonal skills in childhood served as catalysts for better life outcomes at age 31. Higher interpersonal skills led to fewer externalizing, internalizing, and substance use problems, reduced criminality and sexual partners, in addition to increased general health and full-time employment. Improved intrapersonal skills led to greater strength. There were no significant indirect pathways via academic skills. Our findings inform understanding of how a childhood preventive intervention can improve adjustment and behaviors into established adulthood.

Indexed as

Conduct DisorderAdultChildFemaleHumansMaleSubstance-Related DisordersAdulthoodChildhoodInterventionMechanismsPrevention

Identifiers

PMID39392546
PMCPMC12034041

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.