Evidence map›Paper›PMID 39392501›Full record

ArticleMikrochimica acta2024

Parkinson biomarker determination with an Au microflower-enhanced electrochemical immunosensor using non-Faradaic capacitance measurements.

Luiz Otávio Orzari, Laís Canniatti Brazaca, Bruno Campos Janegitz

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Luiz Otávio OrzariDepartment of Nature Sciences, Mathematics and Education, Federal University of São Carlos, Araras, SP, 13600-970, Brazil.
Laís Canniatti BrazacaSão Carlos Institute of Chemistry, University of São Paulo, São Carlos, SP, 13566-590, Brazil.
Bruno Campos JanegitzDepartment of Nature Sciences, Mathematics and Education, Federal University of São Carlos, Araras, SP, 13600-970, Brazil. brunocj@ufscar.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 380632/2023-3Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.504861/2020-00Financiadora de Estudos e Projetos MARTMA, 01.22.0179.00Fundação de Amparo à Pesquisa do Estado de São Paulo #2019/23342-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/10141-2
6 · The paper itself

Abstract

This work comprehends the development and characterization of a carbon black-based electrode modified with Au microflowers to increase its effect as a capacitance biosensor for the determination of PARK7/DJ-1. Due to its high surface-to-volume ratio and biocompatibility, Au particles are suitable for antibody binding, and by monitoring surface capacitance, it is possible to identify the immune-pair interaction. Au microflowers allowed the adequate immobilization of Parkinsonian-related proteins: PARK7/DJ-1 and its antibody. The protein is associated with several antioxidant mechanisms, but its abnormal concentrations or mutations can be the cause of the loss of dopaminergic neurons, leading to Parkinson's disease. The device was characterized by scanning electron microscopy and cyclic voltammetry, revealing the flower-like structures and the electrochemically-interest enhancements they provide, such as increased heterogeneous electron transfer rate coefficient and electroactive area. The self-assembled monolayers of different molecules were optimized with the aid of 2

Indexed as

Biosensing TechniquesElectric CapacitanceElectrochemical TechniquesGoldParkinson DiseaseProtein Deglycase DJ-1Antibodies, ImmobilizedBiomarkersElectrodesHumansImmunoassayLimit of DetectionAntibodies, ImmobilizedBiomarkersGoldPARK7 protein, humanProtein Deglycase DJ-1Au flowersElectrochemical immunosensorModified electrodeNon-Faradaic electrochemical impedance spectroscopyPARK7/DJ-1Parkinson’s disease

Identifiers

PMID39392501

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.