Trial reportThe journal of spinal cord medicine2026
Feasibility and safety of two weeks of blood flow restriction exercise in individuals with spinal cord injury.
Trial report in The journal of spinal cord medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03690700 (The Feasibility and Effects of Low-load Blood-flow Restricted Exercise Following Spinal Cord Injury), which is not on this map. Not yet cited in PubMed.
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The Feasibility and Effects of Low-load Blood-flow Restricted Exercise Following Spinal Cord Injury
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextReduced muscle strength and function are common after spinal cord injury (SCI). While low-load blood flow restriction exercise (BFRE) enhances muscle strength in healthy and clinical populations, its safety and feasibility in individuals with SCI remain underexplored.
objectivesTo investigate the feasibility and safety of low-load BFRE in individuals with incomplete SCI. STUDY
designCase series.
settingSCI rehabilitation center.
participantsSix participants with motor incomplete SCI were enrolled in the study.
interventionA two-week BFRE intervention for the lower limbs was conducted twice weekly at 40% total arterial occlusion pressure, using 30-40% of 1-repetition maximum loads. OUTCOME MEASURES: Feasibility measures, specifically recruitment and eligibility rates and intervention acceptability, were collected. Blood pressure (BP) responses and specific coagulation markers for deep vein thrombosis (DVT) were assessed as safety measures.
resultsRecruitment and eligibility rates were 2.8% and 6.6% for individuals admitted for first-time rehabilitation (subacute SCI) and 8.3% and 13.9% for 4-week readmission rehabilitation stays (chronic SCI), respectively. Intervention acceptability was high, characterized by 95.8% training adherence and low-to-moderate self-reported pain levels. BP responses and changes in C-reactive protein, Fibrinogen, and D-dimer during the intervention remained within clinically acceptable levels.
conclusionBFRE was feasible in an SCI rehabilitation setting despite a low recruitment rate. BFRE imposed no heightened risk of DVT or severe BP fluctuations in the present case series. Additionally, no severe adverse events occurred, and only mild complaints were reported. More extensive safety considerations warrant larger-scale exploration.
trial registrationClinicalTrials.gov identifier: NCT03690700.
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