ArticleRadiology. Imaging cancer2024
Integrating Contrast-enhanced US to O-RADS US for Classification of Adnexal Lesions with Solid Components: Time-intensity Curve Analysis versus Visual Assessment.
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Article in Radiology. Imaging cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
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4 citing papers in PubMed.
- O-RADS for assessment of adnexal lesions: current status, challenges and future directions.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Review
- Contrast-enhanced ultrasound findings of ovarian Sertoli-Leydig cell tumor: a case report with ultrasonographic-pathological insights.BMC women's health · 2025Article
- Improving Ovarian Cancer Detection: Can CEUS Refine the O-RADS System?Radiology. Imaging cancer · 2025Article
- Radiomics and radiogenomics: extracting more information from medical images for the diagnosis and prognostic prediction of ovarian cancer.Military Medical Research · 2024Review
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Authors and funding
13 authors.
Manli Wu *From the Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China (M.W., Y.W., M.S., L.H., X.Z.); Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, China (R.W.); Department of Ultrasound, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.S.); Department of Ultrasound, Children's Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, China (R.Z.); Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xi'an, China (L.M.); Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, China (L.X.); Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, China (H.W.); Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China (T.L.); and Department of Ultrasound, The Third Hospital of BaoGang Group, Maternity Hospital of Bao Tou, Baotou, China (X.M.).ORCID 0000-0003-0024-5596
Ying Wang *From the Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China (M.W., Y.W., M.S., L.H., X.Z.); Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, China (R.W.); Department of Ultrasound, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.S.); Department of Ultrasound, Children's Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, China (R.Z.); Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xi'an, China (L.M.); Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, China (L.X.); Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, China (H.W.); Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China (T.L.); and Department of Ultrasound, The Third Hospital of BaoGang Group, Maternity Hospital of Bao Tou, Baotou, China (X.M.).ORCID 0009-0005-6576-6968
Manting SuFrom the Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China (M.W., Y.W., M.S., L.H., X.Z.); Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, China (R.W.); Department of Ultrasound, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.S.); Department of Ultrasound, Children's Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, China (R.Z.); Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xi'an, China (L.M.); Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, China (L.X.); Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, China (H.W.); Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China (T.L.); and Department of Ultrasound, The Third Hospital of BaoGang Group, Maternity Hospital of Bao Tou, Baotou, China (X.M.).
Ruili WangFrom the Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China (M.W., Y.W., M.S., L.H., X.Z.); Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, China (R.W.); Department of Ultrasound, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.S.); Department of Ultrasound, Children's Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, China (R.Z.); Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xi'an, China (L.M.); Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, China (L.X.); Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, China (H.W.); Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China (T.L.); and Department of Ultrasound, The Third Hospital of BaoGang Group, Maternity Hospital of Bao Tou, Baotou, China (X.M.).ORCID 0000-0003-2709-8979
Xiaofeng SunFrom the Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China (M.W., Y.W., M.S., L.H., X.Z.); Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, China (R.W.); Department of Ultrasound, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.S.); Department of Ultrasound, Children's Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, China (R.Z.); Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xi'an, China (L.M.); Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, China (L.X.); Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, China (H.W.); Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China (T.L.); and Department of Ultrasound, The Third Hospital of BaoGang Group, Maternity Hospital of Bao Tou, Baotou, China (X.M.).
Rui ZhangFrom the Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China (M.W., Y.W., M.S., L.H., X.Z.); Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, China (R.W.); Department of Ultrasound, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.S.); Department of Ultrasound, Children's Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, China (R.Z.); Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xi'an, China (L.M.); Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, China (L.X.); Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, China (H.W.); Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China (T.L.); and Department of Ultrasound, The Third Hospital of BaoGang Group, Maternity Hospital of Bao Tou, Baotou, China (X.M.).
Liang MuFrom the Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China (M.W., Y.W., M.S., L.H., X.Z.); Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, China (R.W.); Department of Ultrasound, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.S.); Department of Ultrasound, Children's Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, China (R.Z.); Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xi'an, China (L.M.); Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, China (L.X.); Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, China (H.W.); Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China (T.L.); and Department of Ultrasound, The Third Hospital of BaoGang Group, Maternity Hospital of Bao Tou, Baotou, China (X.M.).
Li XiaoFrom the Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China (M.W., Y.W., M.S., L.H., X.Z.); Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, China (R.W.); Department of Ultrasound, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.S.); Department of Ultrasound, Children's Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, China (R.Z.); Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xi'an, China (L.M.); Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, China (L.X.); Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, China (H.W.); Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China (T.L.); and Department of Ultrasound, The Third Hospital of BaoGang Group, Maternity Hospital of Bao Tou, Baotou, China (X.M.).
Hong WenFrom the Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China (M.W., Y.W., M.S., L.H., X.Z.); Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, China (R.W.); Department of Ultrasound, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.S.); Department of Ultrasound, Children's Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, China (R.Z.); Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xi'an, China (L.M.); Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, China (L.X.); Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, China (H.W.); Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China (T.L.); and Department of Ultrasound, The Third Hospital of BaoGang Group, Maternity Hospital of Bao Tou, Baotou, China (X.M.).
Tingting LiuFrom the Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China (M.W., Y.W., M.S., L.H., X.Z.); Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, China (R.W.); Department of Ultrasound, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.S.); Department of Ultrasound, Children's Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, China (R.Z.); Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xi'an, China (L.M.); Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, China (L.X.); Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, China (H.W.); Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China (T.L.); and Department of Ultrasound, The Third Hospital of BaoGang Group, Maternity Hospital of Bao Tou, Baotou, China (X.M.).
Xiaotao MengFrom the Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China (M.W., Y.W., M.S., L.H., X.Z.); Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, China (R.W.); Department of Ultrasound, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.S.); Department of Ultrasound, Children's Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, China (R.Z.); Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xi'an, China (L.M.); Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, China (L.X.); Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, China (H.W.); Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China (T.L.); and Department of Ultrasound, The Third Hospital of BaoGang Group, Maternity Hospital of Bao Tou, Baotou, China (X.M.).
Licong Huang *From the Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China (M.W., Y.W., M.S., L.H., X.Z.); Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, China (R.W.); Department of Ultrasound, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.S.); Department of Ultrasound, Children's Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, China (R.Z.); Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xi'an, China (L.M.); Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, China (L.X.); Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, China (H.W.); Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China (T.L.); and Department of Ultrasound, The Third Hospital of BaoGang Group, Maternity Hospital of Bao Tou, Baotou, China (X.M.).ORCID 0009-0004-7048-3893
Xinling Zhang *From the Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China (M.W., Y.W., M.S., L.H., X.Z.); Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, China (R.W.); Department of Ultrasound, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.S.); Department of Ultrasound, Children's Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, China (R.Z.); Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xi'an, China (L.M.); Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, China (L.X.); Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, China (H.W.); Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China (T.L.); and Department of Ultrasound, The Third Hospital of BaoGang Group, Maternity Hospital of Bao Tou, Baotou, China (X.M.).ORCID 0000-0002-7021-3533
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose To compare the diagnostic performance of time-intensity curve (TIC) analysis and subjective visual assessment of contrast-enhanced US (CEUS) when integrated with the Ovarian-Adnexal Reporting and Data System (O-RADS) US risk stratification system for characterizing adnexal lesions with solid components. Materials and Methods In this prospective multicenter study conducted from September 2021 to December 2022, female individuals with suspected adnexal lesions containing solid components detected at routine US were enrolled. All participants underwent preoperative CEUS examinations. Histopathologic findings were used as the reference standard for diagnosis. Lesions were classified according to the O-RADS US system. Enhancement of solid tissue compared with the outer myometrium was evaluated using both TIC analysis and subjective visual assessment. The diagnostic performance of O-RADS alone and each CEUS assessment method when integrated with the O-RADS US system was assessed and compared using receiver operating characteristic curve analysis. Results A total of 180 lesions (80 malignant and 100 benign histopathologic outcomes) in 175 participants (median age, 47 years [IQR, 33-56]) were analyzed. Incorporating CEUS (assessed through both TIC analysis and subjective visual assessment) with O-RADS US showed significantly improved diagnostic performance over O-RADS US alone, with an area under the receiver operating characteristic curve (AUC) of 0.86 (95% CI: 0.80, 0.91) compared with 0.78 (95% CI: 0.71, 0.84). No evidence of a difference was observed between the AUCs of TIC analysis and subjective visual assessment in the enhancement evaluation of solid tissue with CEUS for adnexal malignancy categorization (
Indexed as
Adnexal DiseasesContrast MediaUltrasonographyAdultFemaleHumansImage EnhancementMiddle AgedOvarian NeoplasmsProspective StudiesContrast MediaAdnexal LesionsContrast-enhanced USO-RADSTime-intensity Curve Analysis
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