Article in Journal of immunology (Baltimore, Md. : 1950), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
29 authors.
Jenna K DickDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0003-2553-7536
Jules A SangalaDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0002-6432-4966
Venkatramana D KrishnaDepartment of Veterinary Population Medicine, University of Minnesota, St. Paul, MN.ORCID 0000-0002-1980-5525
Aaron KhaimrajDepartment of Pharmacology, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-2588-0900
Lydia HamelDivision of Critical Care, Children's Hospital and Clinics of Minnesota, Minneapolis, MN.ORCID 0009-0001-3891-7442
Spencer M EricksonDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0003-0220-4712
Dustin HicksDepartment of Pharmacology, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-6934-4050
Yvette SoignerDivision of Hematology, Oncology, and Transplant, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN.
Laura E CovillCenter for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden.
Alexander K JohnsonDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0002-2341-6311
Michael J EhrhardtDivision of Bone Marrow Transplantation and Cellular Therapy, Department of Pediatrics, M Health Fairview Masonic Children's Hospital, Minneapolis, MN.ORCID 0000-0001-8265-8049
Keenan ErnsteVirology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-2988-6429
Petter BrodinUnit for Clinical Pediatrics, Department of Women's and Children's Health, Karolinska Institute, Solna, Sweden.
Richard A KoupVirology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Alka KhaitanRyan White Center for Pediatric Infectious Diseases & Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0001-8547-8756
Carly BaehrDepartment of Pharmacology, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-3395-6776
Beth K ThielenDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0001-5922-0241
Christine M HenzlerMinnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN.ORCID 0000-0003-4566-2211
Caleb SkipperDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0002-0000-8876
Jeffrey S MillerCenter for Immunology, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-0339-4944
Yenan T BrycesonCenter for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden.
Jianming WuDepartment of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, MN.ORCID 0000-0001-9142-7066
Chandy C JohnRyan White Center for Pediatric Infectious Diseases & Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0002-1634-1411
Angela Panoskaltsis-MortariDivision of Bone Marrow Transplantation and Cellular Therapy, Department of Pediatrics, M Health Fairview Masonic Children's Hospital, Minneapolis, MN.ORCID 0000-0003-1802-1785
Alberto OriolesDivision of Critical Care, Children's Hospital and Clinics of Minnesota, Minneapolis, MN.ORCID 0000-0002-3875-9501
Marie E SteinerDivisions of Pediatric Critical Care and Pediatric Hematology/Oncology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0003-4169-1920
Maxim C J CheeranDepartment of Veterinary Population Medicine, University of Minnesota, St. Paul, MN.ORCID 0000-0002-5331-4746
Marco PravetoniDepartment of Pharmacology, University of Minnesota, Minneapolis, MN.ORCID 0000-0003-1036-0184
Geoffrey T HartDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0003-0483-307X
Funding
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Institutional Career Development CoreKL2TR002492 · NCATS · UNIVERSITY OF MINNESOTA · PI INGBAR, DAVID H · 2018 to 2022
$6.3M
IMMUNOLOGY TRAINING PROGRAMT32AI007313 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Carla Rothlin · 1989 to 2026
$5.7M
Acute and Long-Term Impact of SARS-CoV-2 Infection and its Interaction with APOE on Cognitive Function and Neuropathology in Aging and Alzheimer's DiseaseRF1AG077772 · NIA · UNIVERSITY OF MINNESOTA · PI CHEERAN, MAXIM CHACKO-JOSEPH, LI, LING · 2022 to 2022
$2.2M
HHS | NIH | National Center for Advancing Translational Sciences (NCATS) KL2TR002392HHS | NIH | National Center for Advancing Translational Sciences (NCATS) KL2TR002492HHS | NIH | National Center for Advancing Translational Sciences (NCATS) ULTR1002494HHS | NIH | National Institute on Aging (NIA) RF1AG077772HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases (DMID) T32AI007313-34A1NCATS NIH HHS KL2 TR002492NCATS NIH HHS UL1 TR002494NIAID NIH HHS T32 AI007313NIA NIH HHS RF1 AG077772
6 · The paper itself
Abstract
Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of SARS-CoV-2 infection characterized by multiorgan involvement and inflammation. Testing of cellular function ex vivo to understand the aberrant immune response in MIS-C is limited. Despite strong Ab production in MIS-C, SARS-CoV-2 nucleic acid testing can remain positive for 4-6 wk postinfection. Therefore, we hypothesized that dysfunctional cell-mediated Ab responses downstream of Ab production may be responsible for delayed clearance of viral products in MIS-C. In MIS-C, monocytes were hyperfunctional for phagocytosis and cytokine production, whereas NK cells were hypofunctional for both killing and cytokine production. The decreased NK cell cytotoxicity correlated with an NK exhaustion marker signature and systemic IL-6 levels. Potentially providing a therapeutic option, cellular engagers of CD16 and SARS-CoV-2 proteins were found to rescue NK cell function in vitro. Taken together, our results reveal dysregulation in Ab-mediated cellular responses of myeloid and NK cells that likely contribute to the immune pathology of this disease.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
NK Cell and Monocyte Dysfunction in Multisystem Inflammatory Syndrome in Children. · full record | OpenQuestion