Functional RNAi Screening Identifies G2/M and Kinetochore Components as Modulators of TNFα/NF-κB Prosurvival Signaling in Head and Neck Squamous Cell Carcinoma.
Article in Cancer research communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
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2 · The registry
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5 · Who and what money
Authors and funding
18 authors.
Ethan L MorganTumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-6487-5450
Anthony D SalehTumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.ORCID 0009-0004-1141-9576
Shaleeka CorneliusTumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.ORCID 0009-0002-9806-0273
Sophie G CarlsonTumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.ORCID 0009-0007-6686-1494
Tiffany ToniTumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0003-2119-6914
Hui ChengTumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0001-5380-2830
Jun JeonTumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.ORCID 0009-0004-7242-1063
Ramya ViswanathanTumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.ORCID 0009-0001-1117-2559
Xinping YangTumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.ORCID 0009-0004-9278-3619
Christopher SilvinTumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.ORCID 0009-0007-7941-5426
Paul E ClavijoTumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0003-2279-2515
Anastasia L SowersRadiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.ORCID 0000-0002-0841-7068
James B MitchellRadiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.ORCID 0000-0003-1396-6499
Pinar OrmanogluRNAi Screening Facility, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-2384-8253
Madhu Lal NagRNAi Screening Facility, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland.ORCID 0009-0001-0519-8584
Scott E MartinRNAi Screening Facility, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0001-5685-9787
Zhong ChenTumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-5322-5110
Carter Van WaesTumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-9599-5113
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6M
NF-kappaB in pathogenesis and therapy of head and neck cancerZIADC000016 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI VAN WAES, CARTER · 2009 to 2022
significanceHere, RNAi library screening reveals that multiple G2/M and kinetochore components, including TTK/monopolar spindle 1, modulate TNFα-induced NF-κB activation, cell survival, and genotoxicity, underscoring their potential importance as therapeutic targets in HNSCC.
Indexed as
Carcinoma, Squamous CellHead and Neck NeoplasmsKinetochoresNF-kappa BRNA InterferenceSignal TransductionTumor Necrosis Factor-alphaCell Line, TumorCell SurvivalHumansSquamous Cell Carcinoma of Head and NeckNF-kappa BTumor Necrosis Factor-alpha
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Functional RNAi Screening Identifies G2/M and Kinetochore Components as Modulators of TNFα/NF-κB Prosurvival Signaling in Head and Neck Squamous Cell Carcinoma. · full record | OpenQuestion