Evidence map›Paper›PMID 39392311›Full record

ArticleInfection and immunity2024

An anti-Shiga toxin VHH nanobody multimer protects mice against fatal toxicosis when administered intramuscularly as repRNA.

Sally R Robinson, Denise Ann Dayao, Jhon A Medina, Cara J Martone, Anne K Yauch, Troy Hinkley, Jesse H Erasmus, Charles B Shoemaker, Saul Tzipori

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. An RNA-to-RNA pipeline for rapid antiviral antibody development.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sally R RobinsonDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.ORCID 0000-0003-4711-1667
Denise Ann DayaoDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.ORCID 0000-0001-9570-7807
Jhon A MedinaDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Cara J MartoneDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Anne K YauchDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Troy HinkleyHDT Bio Corp., Seattle, Washington, USA.
Jesse H ErasmusHDT Bio Corp., Seattle, Washington, USA.
Charles B ShoemakerDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Saul TziporiDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.ORCID 0000-0003-4429-3856

Funding

Immune-based therapy against STEC intoxication and HUSR01AI155457 · NIAID · TUFTS UNIVERSITY BOSTON · PI SHOEMAKER, CHARLES BIX, TZIPORI, SAUL R · 2021 to 2023
$1.4M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI155457NIAID NIH HHS R01 AI155457
6 · The paper itself

Abstract

Hemolytic uremic syndrome (HUS) is a systemic sequelae from gastrointestinal infection with Shiga toxin (Stx) producing

Indexed as

Single-Domain AntibodiesAnimalsAntibodies, NeutralizingDisease Models, AnimalEscherichia coli InfectionsFemaleHemolytic-Uremic SyndromeInjections, IntramuscularMiceNanoparticlesShiga-Toxigenic Escherichia coliShiga ToxinAntibodies, NeutralizingShiga ToxinSingle-Domain AntibodiesE. coli O157Shiga toxinsStx mouse toxicity modelStx treatment

Identifiers

PMID39392311
PMCPMC11556087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.