Evidence map›Paper›PMID 39392174›Full record

ArticleRNA biology2024

Estrogen receptor alpha (ERα) regulates PARN-mediated nuclear deadenylation and gene expression in breast cancer cells.

Sophia Varriano, Amy Yu, Yu Qing Xu, Devorah M Natelson, Anthony Ramadei, Frida E Kleiman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. ER-Localized DeadenylaseExploration (Beijing, China) · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sophia VarrianoChemistry Department, Hunter College, The City University of New York, New York, NY, USA.
Amy YuChemistry Department, Hunter College, The City University of New York, New York, NY, USA.
Yu Qing XuChemistry Department, Hunter College, The City University of New York, New York, NY, USA.
Devorah M NatelsonChemistry Department, Hunter College, The City University of New York, New York, NY, USA.
Anthony RamadeiChemistry Department, Hunter College, The City University of New York, New York, NY, USA.
Frida E KleimanChemistry Department, Hunter College, The City University of New York, New York, NY, USA.

Funding

RISE Program Hunter College Option IIIR25GM060665 · NIGMS · HUNTER COLLEGE · PI ORTIZ, BENJAMIN D.,, SERRANO, PETER A · 2000 to 2022
$22.8M
TUFCCC/HC Regional Comprehensive Cancer Health PartnershipU54CA221705 · NCI · TEMPLE UNIV OF THE COMMONWEALTH · PI GRACE X. MA · 2018 to 2026
$16.3M
TUFCCC/HC Regional Comprehensive Cancer Health PartnershipU54CA221704 · NCI · HUNTER COLLEGE · PI Ming-Chin Yeh · 2018 to 2026
$10.6M
NCI NIH HHS U54 CA221704NCI NIH HHS U54 CA221705NIGMS NIH HHS R25 GM060665
6 · The paper itself

Abstract

The estrogen signalling pathway is highly dynamic and primarily mediated by estrogen receptors (ERs) that transcriptionally regulate the expression of target genes. While transcriptional functions of ERs have been widely studied, their roles in RNA biology have not been extensively explored. Here, we reveal a novel biological role of ER alpha (ERα) in mRNA 3' end processing in breast cancer cells, providing an alternative mechanism in regulating gene expression at the post-transcriptional level. We show that ERα activates poly(A) specific ribonuclease (PARN) deadenylase using

Indexed as

Breast NeoplasmsEstrogen Receptor alphaExoribonucleasesGene Expression Regulation, NeoplasticRNA, MessengerTumor Suppressor Protein p53Cell Line, TumorCell NucleusFemaleHumansMCF-7 CellsProtein BindingESR1 protein, humanEstrogen Receptor alphaExoribonucleasesRNA, MessengerTumor Suppressor Protein p53Breast cancerdeadenylationestrogen receptor alpha (ERα)mRNA 3’ end processingPARN deadenylasepost-transcriptional regulation

Identifiers

PMID39392174
PMCPMC11487348

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.