Evidence map›Paper›PMID 39392097›Full record

ArticleEuropean journal of neurology2024

Characteristics and temporal evolution of asymptomatic diffusion-weighted imaging lesions in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Ying-Chi Shen, Ya-Fang Chen, Yu-Wen Cheng, Chih-Hao Chen, Jiann-Shing Jeng, Sung-Chun Tang

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05473637 (Deciphering, Construction and Validation of Magnetic Resonance Imaging Maps, Clinical Features and Outcomes in Genetic and Nongenetic Cerebral Small Vessel Diseases), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05473637 recruitingnot on this map

Deciphering, Construction and Validation of Magnetic Resonance Imaging Maps, Clinical Features and Outcomes in Genetic and Nongenetic Cerebral Small Vessel Diseases

Typeobservational_patient_registrySponsorNational Taiwan University HospitalRan2019 to 2028Enrolled500ConditionsCerebral Small Vessel Diseases, Cadasil, HTRA1-Related Autosomal Dominant Cerebral Angiopathy, COL4A1-Related Brain Small Vessel Disease With HaemorrhageArmsMRI
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Evolution of cortical cerebral microinfarcts on 3T MRI: risk factors and clinical relevance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ying-Chi ShenDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan.ORCID 0000-0002-0103-7572
Ya-Fang ChenDepartment of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan.
Yu-Wen ChengDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan.ORCID 0000-0002-3054-6333
Chih-Hao ChenDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan.ORCID 0000-0002-1258-8775
Jiann-Shing JengDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
Sung-Chun TangDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan.

Funding

Academia Sinica, Taiwan AS-GC-111-L04
6 · The paper itself

Abstract

background and purposeThe role of asymptomatic diffusion-weighted imaging-positive (aDWI+) lesions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients remains unclear, and their radiographic features may differ from those of symptomatic diffusion-weighted imaging-positive (sDWI+) lesions. We aimed to investigate the clinicoradiographic characteristics of aDWI+ lesions in CADASIL patients.

methodsWe conducted a retrospective analysis using data from the Taiwan CADASIL Registry. aDWI+ lesions were defined as incidentally detected DWI+ lesions without corresponding acute neurological deficits. We compared the baseline clinical characteristics of patients with and without aDWI+ lesions and analyzed their radiological features and evolution in relation to sDWI+ lesions.

resultsAmong 154 enrolled patients (mean age 62 ± 10 years), 17 (11%) had aDWI+ lesions. Baseline clinical characteristics were similar in the two groups, but those with aDWI+ lesions had more lacunes (median 8 vs. 2), multiple cerebral microbleeds (CMBs; 85% vs. 40%), and anterior temporal white matter hyperintensity (WMH; 47% vs. 14%). Multivariable analysis showed that aDWI+ lesions were associated with anterior temporal WMH (odds ratio 5.7, 95% confidence interval 1.5-21.0) after adjusting for multiple lacunes, multiple CMBs, and total WMH score. Compared to sDWI+ lesions, aDWI+ lesions were more often small infarcts (<1 cm; 89% vs. 23%) and less likely to involve the corticospinal tract (11% vs. 96%). Among the 11 aDWI+ lesions with follow-up magnetic resonance imaging, seven became microinfarcts, three became lacunes, and one disappeared.

conclusionsaDWI+ lesions in CADASIL are not uncommon and are associated with higher burdens of small vessel disease and anterior temporal WMH. Further research is needed to assess their long-term impact on CADASIL.

Indexed as

CADASILDiffusion Magnetic Resonance ImagingAgedDisease ProgressionFemaleHumansMaleMiddle AgedRegistriesRetrospective StudiesTaiwanCADASILcovert brain infarctdiffusion‐weighted imagingNOTCH3 mutationstroke

Identifiers

PMID39392097
PMCPMC11554854

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.