Evidence map›Paper›PMID 39391841›Full record

ArticleJournal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems2020

An integrated, optofluidic system with aligned optical waveguides, microlenses, and coupling prisms for fluorescence sensing.

Daniel S-W Park, Brandon M Young, Byoung H You, Varshni Singh, Steven A Soper, Michael C Murphy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniel S-W ParkCenter for BioModular Multiscale Systems for Precision Medicine, Department of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, USA.
Brandon M YoungJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, NC, USA and is now with the Center for BioModular Multiscale Systems for Precision Medicine, at the University of Kansas, Lawrence, KS 66045.
Byoung H YouDepartment of Engineering Technology, Texas State University, San Marcos, TX 78666, USA.
Varshni SinghCenter for Advanced Microstructures and Devices (CAMD), Louisiana State University, Baton Rouge, LA 70806, USA.
Steven A SoperCenter for BioModular Multiscale Systems for Precision Medicine, Departments of Chemistry and Mechanical Engineering, University of Kansas, Lawrence, KS, 66045, USA.
Michael C MurphyCenter for BioModular Multiscale Systems for Precision Medicine, Department of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, USA.

Funding

Single-Molecule Processing: Detection and Identification of Single DNAs, RNAs, and Proteins using Immobilized Nanoscale Enzymatic Reactors (INERs) and Nanoscale ElectrophoresisP41EB020594 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Adam Roger Hall · 2015 to 2026
$15.2M
spFRET for Expression Profiling mRNA: Discovering Markers for Stroke DiagnosisR01EB010087 · NIBIB · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI BAIRD, ALISON E, SOPER, STEVEN ALLAN · 2011 to 2014
$2.5M
NIBIB NIH HHS P41 EB020594NIBIB NIH HHS R01 EB010087
6 · The paper itself

Abstract

An improved, laser-induced fluorescence-based micro-optical biosensor was designed and fabricated, with cyclic olefin copolymer (COC) optical waveguides, a poly(methyl methacrylate) (PMMA) fluidic substrate with an array of microlenses, and a COC coupling prism integrated with the waveguide substrate or cover plate. The double-sided hot embossed fluidic substrate had sampling zone microchannels on the bottom and microlenses on the top. Dissolved COC injected into polydimethylsiloxane (PDMS) lost molds embedded the waveguides in the PMMA cover plate and formed the integrated coupling prism. The embedded COC waveguide was flycut down to 50 μm. The cover plate and shallow, 1:20 aspect ratio, microchannels were thermal fusion bonded using a pressure-assisted boiling point control system, without sagging. The large COC prism coupled better to the waveguide. The highest intensity evanescent excitation of the waveguide was obtained near the critical angle. The maximum signal-to-noise ratio (SNR) was 119 and the lowest detection limit was 7.34 × 10

Indexed as

Hot EmbossingMicrolensesPrismWaveguide

Identifiers

PMID39391841
PMCPMC11465942

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.