Evidence map›Paper›PMID 39391731›Full record

ArticleiScience2024

Deciphering the role of endothelial granulocyte macrophage-CSF in chronic inflammation associated with HIV.

Soumya Panigrahi, Elizabeth Mayne, Susan Louw, Nicholas T Funderburg, Archeesha Chakraborty, Jeffrey M Jacobson, Stephen M Carpenter, Michael M Lederman, Michael L Freeman, Scott F Sieg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Soumya PanigrahiDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Elizabeth MayneDivision of Immunology, Department of Pathology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Service, Cape Town, South Africa.
Susan LouwDepartment of Molecular Medicine and Hematology, School of Pathology, Faculty of Health Sciences, and National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa.
Nicholas T FunderburgSchool of Health and Rehabilitation Sciences, Ohio State University, Columbus, OH, USA.
Archeesha ChakrabortyDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Jeffrey M JacobsonDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Stephen M CarpenterDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Michael M LedermanDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Michael L FreemanDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Scott F SiegDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Funding

WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Immaculate Lillian Nankya · 1994 to 2026
$50.0M
Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1M
Determining Protective Features of Human Memory T-cells to Inform Mycobacterium tuberculosis Vaccine DevelopmentK08AI163407 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Stephen Matthew Carpenter · 2022 to 2026
$967k
Determining the mechanisms of vascular CD8 T cell activation in CMV and HIV infectionsR21AI162150 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI FREEMAN, MICHAEL L · 2021 to 2022
$443k
Overcoming restrained lung trafficking by memory CD4+ T cells to prevent active tuberculosis in people living with HIVR21AI167675 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI CARPENTER, STEPHEN MATTHEW, FREEMAN, MICHAEL L · 2022 to 2023
$443k
NCATS NIH HHS UM1 TR004528NIAID NIH HHS K08 AI163407NIAID NIH HHS P30 AI036219NIAID NIH HHS R21 AI162150NIAID NIH HHS R21 AI167675
6 · The paper itself

Abstract

People with HIV (PWH) experience endothelial dysfunction (ED) that is aggravated by chronic inflammation and microbial translocation across a damaged gut barrier. Although this paradigm is well-described, downstream pathways that terminate in endothelial dysfunction are only partially understood. This study found increased expression of granulocyte macrophage colony stimulating factor (GM-CSF), toll-like receptor-4 (TLR4), and myeloperoxidase in the aortic endothelium of PWH compared to those without HIV. Bacteria-derived lipopolysaccharide (LPS) heightened glucose uptake and induced GM-CSF expression in primary human endothelial cells. Exposure to sodium-glucose cotransporter-2 (SGLT2) inhibitors reduced glucose uptake, GM-CSF release, and ED in LPS-activated endothelial cells

Indexed as

Cell biologyImmunologyMolecular biologyVirology

Identifiers

PMID39391731
PMCPMC11465086

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.