Evidence map›Paper›PMID 39391444›Full record

ArticleCureus2024

Severe Anaphylaxis From Remimazolam in a Mastocytosis Cancer Patient: A Case Report.

Julie Mani, Amanda Strang, Adeel A Faruki, Zuhair A Siddiqui, Gabriel Mena

Abstract readCase Reports
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Julie ManiDepartment of Anesthesiology and Perioperative Medicine, MD Anderson Cancer Center, Houston, USA.
Amanda StrangDepartment of Anesthesiology and Perioperative Medicine, McGovern Medical School at UTHealth, Houston, USA.
Adeel A FarukiDepartment of Anesthesiology and Perioperative Medicine, MD Anderson Cancer Center, Houston, USA.
Zuhair A SiddiquiDepartment of Anesthesiology and Perioperative Medicine, MD Anderson Cancer Center, Houston, USA.
Gabriel MenaDepartment of Anesthesiology and Perioperative Medicine, MD Anderson Cancer Center, Houston, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Remimazolam besylate is a novel, rapid-onset, ultra-short-acting benzodiazepine with an advantageous cardio-respiratory safety profile. To date, there have been few published reports of remimazolam-induced anaphylaxis, none of which are documented in patients with mast cell disease. We describe the case of a 77-year-old male with oncologic mastocytosis who developed anaphylaxis following remimazolam administration. Symptoms included shortness of breath, hypoxia, loss of consciousness, tachycardia, and hypotension. Resolution of symptoms was attained after the administration of flumazenil, dexamethasone, diphenhydramine, famotidine, and phenylephrine. Suspicion of an anaphylactic reaction was confirmed by elevated serum tryptase levels. This case report helps establish how to diagnose anaphylaxis in a mastocytosis patient.

Indexed as

anaphylaxisanesthesiologymastocytosisoncologyremimazolam

Identifiers

PMID39391444
PMCPMC11465966

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.