Evidence map›Paper›PMID 39391329›Full record

ArticleBJC reports2024

Tumour reoxygenation after intratumoural hydrogen peroxide (KORTUC) injection: a novel approach to enhance radiosensitivity.

Samantha Nimalasena, Selvakumar Anbalagan, Carol Box, Sheng Yu, Jessica K R Boult, Nigel Bush, Louise Howell, Victoria Sinnett, William Murphy, John Yarnold and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJC reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Samantha Nimalasena *Division of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK.
Selvakumar Anbalagan *Division of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK.
Carol BoxDivision of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK.
Sheng YuDivision of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK.
Jessica K R BoultDivision of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK.
Nigel BushDivision of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK.
Louise HowellCore Research Facilities, The Institute of Cancer Research, London, UK.
Victoria SinnettThe Royal Marsden NHS Foundation Trust, London, UK.
William MurphyBiological Service Unit, The Institute of Cancer Research, London, UK.
John YarnoldDivision of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK.
Simon P RobinsonDivision of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK.
Navita SomaiahDivision of Radiotherapy & Imaging, The Institute of Cancer Research, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: KORTUC (0.5% hydrogen peroxide (H Methods and materials: Pimonidazole and Image-iT™ Red (live hypoxia marker) were utilised to assess dose-dependent changes in hypoxia post-H Results: A significant reduction in Image-iT™ Red fluorescence was observed in spheroids 1 h post-H Conclusion: Intratumoural KORTUC represents a novel oxygen delivery method, which can be exploited to enhance radiation response. If efficacy is confirmed in the ongoing phase 2 breast trial it could improve treatment of several tumour types where hypoxia is known to affect radiotherapy outcomes.

Identifiers

PMID39391329
PMCPMC11461272

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.