Evidence map›Paper›PMID 39391304›Full record

ArticleFrontiers in immunology2024

Novel RNA biomarkers improve discrimination of children with tuberculosis disease from those with non-TB pneumonia after

Ortensia Vito, Stelios Psarras, Angeliki Syggelou, Victoria J Wright, Virginia Amanatidou, Sandra M Newton, Hannah Shailes, Katerina Trochoutsou, Maria Tsagaraki, Michael Levin and 2 more

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ortensia VitoDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.
Stelios PsarrasCenter of Basic Research, Biomedical Research Foundation, Academy of Athens , Athens, Greece.
Angeliki SyggelouSecond Department of Pediatrics, National and Kapodistrian University of Athens (NKUA), School of Medicine, P. and A. Kyriakou Children's Hospital, Athens, Greece.
Victoria J WrightDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.
Virginia AmanatidouSecond Department of Pediatrics, National and Kapodistrian University of Athens (NKUA), School of Medicine, P. and A. Kyriakou Children's Hospital, Athens, Greece.
Sandra M NewtonDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.
Hannah ShailesDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.
Katerina TrochoutsouSecond Department of Pediatrics, National and Kapodistrian University of Athens (NKUA), School of Medicine, P. and A. Kyriakou Children's Hospital, Athens, Greece.
Maria TsagarakiSecond Department of Pediatrics, National and Kapodistrian University of Athens (NKUA), School of Medicine, P. and A. Kyriakou Children's Hospital, Athens, Greece.
Michael Levin *Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.
Myrsini Kaforou *Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.
Maria Tsolia *Second Department of Pediatrics, National and Kapodistrian University of Athens (NKUA), School of Medicine, P. and A. Kyriakou Children's Hospital, Athens, Greece.

Funding

MRF_ MRF-160-0008-ELP-KAFO-C0801Wellcome Trust
6 · The paper itself

Abstract

The diagnosis of pediatric tuberculosis (TB) poses a challenge for clinical teams worldwide. TB-mediated changes in the expression of host genes in the peripheral blood can serve as diagnostic biomarkers and can provide better insights into the host immune mechanisms of childhood TB. Peripheral blood mononuclear cells (PBMCs) from children (n=102) with microbiologically confirmed TB disease, TB infection (TBI), pneumonia, and healthy controls (HC) were stimulated with either the Purified Protein Derivative (PPD) or the Early Secretory Antigen 6kDa-Culture Filtrate Protein 10 (ESAT6-CFP10) complex of

Indexed as

BiomarkersMycobacterium tuberculosisTuberculosisAdolescentAntigens, BacterialBacterial ProteinsChildChild, PreschoolDiagnosis, DifferentialFemaleGene Expression ProfilingHumansInfantLeukocytes, MononuclearMalePneumoniaAntigens, BacterialBacterial ProteinsBiomarkersRNAbiomarkersPBMCperipheral immunity signaturesstimulanttranscriptomicstuberculosis

Identifiers

PMID39391304
PMCPMC11464340

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.