Evidence map›Paper›PMID 39391272›Full record

ReviewEngineering in life sciences2024

Microbial Squalene: A Sustainable Alternative for the Cosmetics and Pharmaceutical Industry - A Review.

Saseendran Shalu, Panam Kunnel Raveendranathan Karthikanath, Vinoth Kumar Vaidyanathan, Lars M Blank, Andrea Germer, Palanisamy Athiyaman Balakumaran

Abstract readReview
In one paragraph

Review in Engineering in life sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Optimization of Squalene Production byMolecules (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Saseendran ShaluDepartment of Molecular Biology and Biotechnology College of Agriculture Kerala Agricultural University Vellayani Kerala India.
Panam Kunnel Raveendranathan KarthikanathChemical Sciences and Technology Division CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST) Thiruvananthapuram Kerala India.
Vinoth Kumar VaidyanathanIntegrated Bioprocessing Laboratory Department of Biotechnology School of Bioengineering SRM Institute of Science and Technology (SRMIST) Kattankulathur India.
Lars M BlankiAMB - Institute of Applied Microbiology ABBt - Aachen Biology and Biotechnology RWTH Aachen University Aachen Germany.
Andrea GermeriAMB - Institute of Applied Microbiology ABBt - Aachen Biology and Biotechnology RWTH Aachen University Aachen Germany.
Palanisamy Athiyaman BalakumaranChemical Sciences and Technology Division CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST) Thiruvananthapuram Kerala India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Squalene is a natural triterpenoid and a biosynthetic precursor of steroids and hopanoids in microorganisms, plants, humans, and other animals. Squalene has exceptional properties, such as its antioxidant activity, a high penetrability of the skin, and the ability to trigger the immune system, promoting its application in the cosmetic, sustenance, and pharmaceutical industries. Because sharks are the primary source of squalene, there is a need to identify low-cost, environment friendly, and sustainable alternatives for producing squalene commercially. This shift has prompted scientists to apply biotechnological advances to research microorganisms for synthesizing squalene. This review summarizes recent metabolic and bioprocess engineering strategies in various microorganisms for the biotechnological production of this valuable molecule.

Indexed as

metabolic engineeringsqualenesynthetic biologytriterpeneyeast

Identifiers

PMID39391272
PMCPMC11464149

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.