Evidence map›Paper›PMID 39391077›Full record

ArticleJournal of mood and anxiety disorders2024

Smaller hippocampal volume is associated with anxiety symptoms in high-risk Black youth.

Rebecca Lipschutz, Abigail Powers, Sean T Minton, Anais F Stenson, Timothy D Ely, Jennifer S Stevens, Tanja Jovanovic, Sanne J H van Rooij

Abstract read
In one paragraph

Article in Journal of mood and anxiety disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rebecca LipschutzDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Abigail PowersDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Sean T MintonDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Anais F StensonDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
Timothy D ElyDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Tanja JovanovicDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
Sanne J H van RooijDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.

Funding

Impact of Trauma Exposure on Critical Periods in Brain Development and Fear Processing in ChildrenR01MH111682 · NIMH · WAYNE STATE UNIVERSITY · PI JOVANOVIC, TANJA · 2016 to 2020
$3.0M
Mechanisms of Intergenerational Impact of Maternal TraumaR01HD071982 · NICHD · EMORY UNIVERSITY · PI BRADLEY, BEKH · 2013 to 2017
$2.1M
Effect of TMS on PTSD Neuroimaging and Psychophysiological BiomarkersK01MH121653 · NIMH · EMORY UNIVERSITY · PI VAN ROOIJ, SANNE JH · 2020 to 2024
$894k
NICHD NIH HHS R01 HD071982NIMH NIH HHS K01 MH121653NIMH NIH HHS R01 MH111682
6 · The paper itself

Abstract

Although there is an established link between smaller hippocampal volume and anxiety, the longitudinal relations between hippocampus structure and anxiety in diverse youth are not well understood. The present longitudinal study investigated hippocampal volumes related to anxiety symptoms in a sample of Black 8-14-year-old youth (N = 64), a population historically underrepresented in neuroimaging research. Smaller hippocampal volumes were associated with greater anxiety symptoms independent of age, sex, intracranial volume and trauma exposure. Exploratory longitudinal analyses showed smaller hippocampal volume as a predictor for anxiety symptoms (n = 37) and not a consequence of anxiety symptoms (n = 32), however results were inconclusive as this finding was no longer significant after correcting for baseline anxiety symptoms. Overall, this data increases our understanding of potential neurobiological mechanisms for anxiety in a high-risk sample of Black youth and suggests future directions into studying trajectories of developmental risk.

Indexed as

AnxietyHippocampusNeuroimagingTraumaYouth

Identifiers

PMID39391077
PMCPMC11466052

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.