Evidence map›Paper›PMID 39391052›Full record

ArticleNeurotrauma reports2024

Neuromodulation in Spinal Cord Injury Using Transcutaneous Spinal Stimulation-Mapping for a Blood Pressure Response: A Case Series.

Einat Engel-Haber, Akhil Bheemreddy, Mehmed Bugrahan Bayram, Manikandan Ravi, Fan Zhang, Haiyan Su, Steven Kirshblum, Gail F Forrest

Registry-linked trialAbstract read
In one paragraph

Article in Neurotrauma reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06841198 (Assessing Cardiovascular Effects), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06841198 narecruitingnot on this mapstarted 2025, after this paper: background citation

Assessing Cardiovascular Effects: Is There a Time Too Early for Spinal Stimulation in Acute SCI? A Year-Long Evaluation of Autonomic Function Following Injury

TypeinterventionalSponsorKessler FoundationRan2025 to 2026Enrolled15ConditionsSpinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal StimulationArmsspinal cord transcutaneous stimulation, Ice testing
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Cardiovascular safety of transcutaneous spinal cord stimulation in cervical spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Einat Engel-HaberKessler Foundation, West Orange, New Jersey, USA.ORCID https://orcid.org/0000-0001-5684-3072
Akhil BheemreddyKessler Foundation, West Orange, New Jersey, USA.
Mehmed Bugrahan BayramKessler Foundation, West Orange, New Jersey, USA.
Manikandan RaviKessler Foundation, West Orange, New Jersey, USA.
Fan ZhangKessler Foundation, West Orange, New Jersey, USA.
Haiyan SuSchool of Computing, Montclair State University, Montclair, New Jersey, USA.
Steven KirshblumKessler Foundation, West Orange, New Jersey, USA.
Gail F ForrestKessler Foundation, West Orange, New Jersey, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord transcutaneous stimulation (scTS) offers a promising approach to enhance cardiovascular regulation in individuals with a high-level spinal cord injury (SCI), addressing the challenges of unstable blood pressure (BP) and the accompanying hypo- and hypertensive events. While scTS offers flexibility in stimulation locations, it also leads to significant variability and lack of validation in stimulation sites utilized by studies. Our study presents findings from a case series involving eight individuals with chronic cervical SCI, examining the hemodynamic effects of scTS applied in different vertebral locations, spanning from high cervical to sacral regions. Stimulation of the lumbosacral vertebrae region (L1/2, S1/2, and also including T11/12) significantly elevated BP, unlike cervical or upper thoracic stimulation. The observed trend, which remained consistent across different participants, highlights the promising role of lumbosacral stimulation in neuromodulating BP.

Indexed as

blood pressurecardiovascularmappingspinal cord injuryspinal cord stimulationspinal cord transcutaneous stimulation

Identifiers

PMID39391052
PMCPMC11462428

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.