ArticleFrontiers in cardiovascular medicine2024
White blood cell counts can predict 4-year cardiovascular disease risk in patients with stable coronary heart disease: a prospective cohort study.
Article in Frontiers in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00799903 (LPL100601, A Clinical Outcomes Study of Darapladib Versus Placebo in Subjects With Chronic Coronary Heart Disease to Compare the Incidence of Major Adverse Cardiovascular Events), which is not on this map. Cited by 7 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
LPL100601, A Clinical Outcomes Study of Darapladib Versus Placebo in Subjects With Chronic Coronary Heart Disease to Compare the Incidence of Major Adverse Cardiovascular Events (MACE)
Who cites it
7 citing papers in PubMed.
- Article
- Hematological markers of proinflammatory and prothrombotic states in normal-weight obesity (NWO).Scientific reports · 2026Article
- Association of Inflammatory-Hematological Biomarkers with Hypertension and Related Comorbidities.Journal of clinical medicine · 2026Article
- Interferon Gamma and Tumor Necrosis Factor Alpha Are Inflammatory Biomarkers for Major Adverse Cardiovascular Events in Patients with Peripheral Artery Disease.Biomedicines · 2025Article
- Development of a nomogram model for predicting coronary heart disease in patients with metabolic-associated fatty liver disease.Frontiers in cardiovascular medicine · 2025Article
- Association between inflammatory score, healthy lifestyle, and cardiovascular disease: a national cohort study.Frontiers in nutrition · 2025Article
- Troponin at presentation: A key predictor of chronic myocardial impairment post-myocarditis-A prospective cohort study.JRSM cardiovascular diseaseArticle
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Authors and funding
10 authors.
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Abstract
Background: The prevalence of cardiovascular disease has increased sharply in the Asian population, and evaluation of the risk of cardiovascular events with stable coronary heart disease remains challenging. The role of white blood cell (WBC) count in assisting clinical decision-making in this setting is still unclear. Objectives: This study sought to evaluate the prognostic meaning of WBC count among patients with stable coronary heart disease. Methods: This study included Asian participants ( Results: In the lower WBC count quartiles, patients had lower-risk clinical profiles. Higher WBC counts were associated with greater event probabilities for cardiovascular death, major cardiovascular events, or all-cause death. In Cox regression models, WBC counts were an independent predictor of major adverse cardiovascular events (OR = 2.445, 95% CI 1.427-4.190, Conclusions: In patients with stable coronary heart disease, higher WBC counts were associated with a heightened risk for the primary or secondary outcomes. Registration: https://clinicaltrials.gov/; Unique identifier NCT00799903.
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