Evidence map›Paper›PMID 39390592›Full record

ArticleGenome biology2024

Transipedia.org: k-mer-based exploration of large RNA sequencing datasets and application to cancer data.

Chloé Bessière, Haoliang Xue, Benoit Guibert, Anthony Boureux, Florence Rufflé, Julien Viot, Rayan Chikhi, Mikaël Salson, Camille Marchet, Thérèse Commes and 1 more

Abstract read
In one paragraph

Article in Genome biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chloé Bessière *IRMB, INSERM U1183, Hopital Saint-Eloi, Universite de Montpellier, Montpellier, France.
Haoliang Xue *I2BC, Université Paris-Saclay, CNRS, CEA, Gif sur Yvette, France.
Benoit Guibert *IRMB, INSERM U1183, Hopital Saint-Eloi, Universite de Montpellier, Montpellier, France.
Anthony Boureux *IRMB, INSERM U1183, Hopital Saint-Eloi, Universite de Montpellier, Montpellier, France.
Florence RuffléIRMB, INSERM U1183, Hopital Saint-Eloi, Universite de Montpellier, Montpellier, France.
Julien ViotDepartment of Medical Oncology, Biotechnology and Immuno-Oncology Platform, University Hospital of Besançon, Besançon, France.
Rayan ChikhiInstitut Pasteur, Université Paris Cité, Paris, France.
Mikaël SalsonUniversité de Lille, CNRS, Centrale Lille, UMR 9189 CRIStAL, F-59000, Lille, France.
Camille MarchetUniversité de Lille, CNRS, Centrale Lille, UMR 9189 CRIStAL, F-59000, Lille, France.
Thérèse CommesIRMB, INSERM U1183, Hopital Saint-Eloi, Universite de Montpellier, Montpellier, France. therese.commes@inserm.fr.
Daniel GautheretI2BC, Université Paris-Saclay, CNRS, CEA, Gif sur Yvette, France. daniel.gautheret@universite-paris-saclay.fr.ORCID http://orcid.org/0000-0002-1508-8469

Funding

Agence Nationale de la Recherche ANR-19-CE45-0008Agence Nationale de la Recherche ANR-19-P3IA-0001Agence Nationale de la Recherche ANR-22- CE45-0007
6 · The paper itself

Abstract

Indexing techniques relying on k-mers have proven effective in searching for RNA sequences across thousands of RNA-seq libraries, but without enabling direct RNA quantification. We show here that arbitrary RNA sequences can be quantified in seconds through their decomposition into k-mers, with a precision akin to that of conventional RNA quantification methods. Using an index of the Cancer Cell Line Encyclopedia (CCLE) collection consisting of 1019 RNA-seq samples, we show that k-mer indexing offers a powerful means to reveal non-reference sequences, and variant RNAs induced by specific gene alterations, for instance in splicing factors.

Indexed as

NeoplasmsSequence Analysis, RNACell Line, TumorHumansRNA-SeqSoftwareBioinformaticsNon-coding RNARNA-processingRNA-seqTranscriptomics

Identifiers

PMID39390592
PMCPMC11468207

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.