Evidence map›Paper›PMID 39390590›Full record

ArticleActa neuropathologica communications2024

A pathogenic mutation in the ALS/FTD gene VCP induces mitochondrial hypermetabolism by modulating the permeability transition pore.

Silke Vanderhaeghe, Jovan Prerad, Arun Kumar Tharkeshwar, Elien Goethals, Katlijn Vints, Jimmy Beckers, Wendy Scheveneels, Eveline Debroux, Katrien Princen, Philip Van Damme and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Silke Vanderhaeghe *Laboratory of Neurobiology, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.
Jovan Prerad *reMYND, Leuven, Belgium.
Arun Kumar TharkeshwarDepartment of Human Genetics, KU Leuven - University of Leuven, Leuven, Belgium.
Elien GoethalsLaboratory of Neurobiology, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.
Katlijn VintsElectron Microscopy Platform and VIB-Bioimaging Core, VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
Jimmy BeckersLaboratory of Neurobiology, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.
Wendy ScheveneelsLaboratory of Neurobiology, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.
Eveline DebrouxreMYND, Leuven, Belgium.
Katrien PrincenreMYND, Leuven, Belgium.
Philip Van DammeLaboratory of Neurobiology, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.
Marc FivazreMYND, Leuven, Belgium. marc.fivaz@remynd.com.
Gerard GriffioenreMYND, Leuven, Belgium. gerard.griffioen@ext.remynd.com.
Ludo Van Den BoschLaboratory of Neurobiology, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium. ludo.vandenbosch@kuleuven.be.

Funding

Flanders Innovation & Entrepreneurship (VLAIO) 030383VLAIO Baekeland mandate HBC.2019.2575
6 · The paper itself

Abstract

Valosin-containing protein (VCP) is a ubiquitously expressed type II AAA

Indexed as

Amyotrophic Lateral SclerosisFrontotemporal DementiaMitochondriaMitochondrial Permeability Transition PoreMutationValosin Containing ProteinCalciumCell Line, TumorHumansMembrane Potential, MitochondrialMitochondrial Membrane Transport ProteinsCalciumMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreValosin Containing ProteinVCP protein, humanAmyotrophic lateral sclerosisFrontotemporal dementiaMitochondriaMitochondrial dysfunctionMitochondrial permeability transition poreVCP

Identifiers

PMID39390590
PMCPMC11465669

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.