Evidence map›Paper›PMID 39390428›Full record

ArticleBMC gastroenterology2024

Reduced muscle mass is an important part of Global Leadership Initiative on Malnutrition criteria in nutritional diagnosis of hepatocellular carcinoma.

Juan Li, Minjie Jiang, Xin Hua, Hongxia Xu, Muchen Wu, Jing Wu, Songtao Liu, Hanping Shi, Qinghua Meng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. [The value of the nutritional assessment index or score in prognostic evaluation for patients with liver cancer].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  4. Review
  5. Changes in nutritional status in hepatocellular carcinoma patients treated with sorafenib.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Juan Li *Department of Clinical Oncology, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Minjie Jiang *Department of Clinical Oncology, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Xin Hua *Department of Nutrition, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Hongxia XuDepartment of Nutrition, Daping Hospital & Research Institute of Surgery, Third Military Medical University, Chongqing, China.
Muchen WuDepartment of Clinical Oncology, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Jing WuDepartment of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Songtao LiuDepartment of Clinical Oncology, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Hanping ShiDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, China.
Qinghua MengDepartment of Clinical Oncology, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China. meng_qh0805@ccmu.edu.cn.

Funding

Internal Project of Beijing Youan Hospital Capital Medical University YNKTLC2021005
6 · The paper itself

Abstract

backgroundThe Global Leadership Initiative on Malnutrition criteria (GLIM) was established to build a global consensus on the diagnostic criteria for malnutrition. The study aimed to assess the prevalence of the malnutrition diagnosed by GLIM criteria for patients with hepatocellular carcinoma (HCC), and to determine the role of the reduced muscle mass defined by CT scans in the GLIM criteria.

methodsThis cohort research was conducted on adult cirrhotic patients with HCC. The risk of malnutrition was screened by Nutritional Risk Screening 2002 (NRS-2002), and malnutrition was diagnosed by GLIM criteria. The third lumbar vertebrae (L3-SMI) were used to represent the muscle mass in GLIM criteria. The variables associated with overall mortality were assessed by multivariate Cox regression analyses.

resultsThe incidence of malnutrition diagnosed by GLIM criteria was 49.7% (179/360) in patients with HCC. If reduced muscle mass was not included in GLIM criteria, the prevalence of malnutrition was 31.7% (114/360). GLIM-defined malnutrition (HR = 1.979, 95%CI 1.019-3.841, P = 0.044) was independently associated with overall mortality in patients with HCC. However, the GLIM-defined malnutrition (without muscle mass) was not associated with overall mortality (HR = 0.863, 95%CI 0.399-1.867, P = 0.709).

conclusionsSkeletal muscle mass is an integral component of the GLIM criteria for patients with HCC. The malnutrition is common in patients with HCC, and malnourishment is associated with higher overall mortality. GLIM criteria are recommended to assess the nutritional status of hospitalized patients with HCC, which is recommended and can be used as the basis for nutritional interventions.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsMalnutritionTomography, X-Ray ComputedAgedFemaleHumansLiver CirrhosisMaleMiddle AgedMuscle, SkeletalNutritional StatusNutrition AssessmentPrevalenceSarcopeniaChronic liver diseaseClinical outcomesHepatocellular carcinomaMalnutritionSkeletal muscle mass

Identifiers

PMID39390428
PMCPMC11465919

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.