Evidence map›Paper›PMID 39390409›Full record

ArticleBMC microbiology2024

High prevalence of colonization with extended-spectrum β-lactamase-producing and multidrug-resistant Enterobacterales in the community in Addis Ababa Ethiopia: risk factors, carbapenem resistance, and molecular characterization.

Dessie Abera, Abel Abera Negash, Surafel Fentaw, Yonas Mekonnen, Raffaele Joseph Cataldo, Ashenafi Alemu Wami, Adane Mihret, Woldaregay Erku Abegaz

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Article in BMC microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dessie AberaDepartment of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. dessabera@gmail.com.
Abel Abera NegashArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Surafel FentawEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Yonas MekonnenEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Raffaele Joseph CataldoArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Ashenafi Alemu WamiArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Adane MihretArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Woldaregay Erku AbegazDepartment of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlobally, extended-spectrum beta-lactamase-producing and carbapenem-resistant Enterobacterales are major causes of hospital-acquired infections and there are increasing concerns about their role in community-acquired infections.

objectiveWe aimed to investigate the prevalence of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) and Carbapenemase-producing-Carbapenemresistant-Enterobacterales (CP-CRE) and associated factors in community settings in Gulele sub city, Addis Ababa, Ethiopia.

methodsA cross-sectional study was conducted among 261 healthy individuals. Stool samples were collected and processed using standard microbiological methods. Antimicrobial susceptibility and phenotypic ESBL and carbapenemase tests were performed. Antibiotic resistance genes were detected by Polymerase Chain Reaction (PCR).

resultsThe colonization rate of ESBL-PE and CP-CRE were 31.4% (82/261, 95% CI: 25.91-37.48) and 0.8% (2/261, 95% CI: 0.13-3.1), respectively by phenotypic method. Molecular detection of genes for ESBL-PE was 27.9% (73/261, 95% CI:22.7-33.9), and for CP-CRE was 0.8% (2/261, 95% CI: 0.13-3.1). The most prevalent genes were blaTEM [76.7% (56/73)] and blaCTX-M [45.2% (33/73)]. Previous antibiotic use (AOR:2.04, 95%CI: 1.35-4.41, P:0.041) and age between 42 and 53 years old (AOR:3.00, 95%CI:1.12-7.48, P:0.019) were significantly associated with ESBL-PE colonization.

conclusionIntestinal colonization by ESBL-PE harboring the associated antibiotic resistance genes was substantially high but with low CP-CRE. Continued surveillance of community-level carriage of antimicrobial resistance Enterobacterales is warranted.

Indexed as

Anti-Bacterial Agentsbeta-LactamasesDrug Resistance, Multiple, BacterialEnterobacteriaceae InfectionsFecesAdolescentAdultAgedBacterial ProteinsCarbapenemsChildCommunity-Acquired InfectionsCross-Sectional StudiesEnterobacteriaceaeEthiopiaFemaleAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenemsAntimicrobial resistanceColonizationGut

Identifiers

PMID39390409
PMCPMC11465526

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.