Evidence map›Paper›PMID 39390361›Full record

ReviewMolecular medicine (Cambridge, Mass.)2024

Occurrence and role of Tph cells in various renal diseases.

Junyi Ren, Kuai Ma, Xiangheng Lu, Haoyu Peng, Jia Wang, Moussa Ide Nasser, Chi Liu

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular medicine (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Junyi Ren *School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Kuai Ma *Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
Xiangheng LuDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Haoyu PengSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Jia WangGeneral Practice Center, Sichuan Provincial People's Hospital, Sichuan Academy of Sciences, University of Electronic Science and Technology, Chengdu, 610072, China.
Moussa Ide NasserDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510100, Guangdong, China. moussa@gdph.org.cn.ORCID 0000-0003-3685-748X
Chi LiuDepartment of Nephrology and Institute of Nephrology, Sichuan Provincial People's Hospital, Sichuan Clinical Research Centre for Kidney Diseases, Chengdu, China. liuchi_1230@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new population of peripheral helper T (Tph) cells has been identified and contributed to various autoimmune diseases. Tph cells can secrete interleukin-21 (IL-21), interferon (IFN) and C-X-C motif chemokine ligand 13 (CXCL13) to moderate renal disease. Moreover, Tph cells can congregate in huge numbers and immerse within inflamed tissue. Compared to Tfh cells, Tph cells express high programmed cell death protein 1 (PD-1), major histocompatibility complex II (MHC-II), C-C chemokine receptor 2 (CCR2) and C-C chemokine receptor 5 (CCR5) but often lack expression of the chemokine receptor C-X-C chemokine receptor 5 (CXCR5). They display features distinct from other T cells, which are uniquely poised to promote responses and antibody production of B cells within pathologically inflamed non-lymphoid tissues and a key feature of Tph cells. In this review, we summarize recent findings on the role of Tph cells in chronic kidney disease, acute kidney injury, kidney transplantation and various renal diseases.

Indexed as

Kidney DiseasesT-Lymphocytes, Helper-InducerAnimalsBiomarkersDisease SusceptibilityHumansBiomarkersAutoimmune nephropathyPeripheral helper T cellsRenal diseasesT follicular helper T cells

Identifiers

PMID39390361
PMCPMC11468416

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.