Evidence map›Paper›PMID 39390328›Full record

ArticlePediatric obesity2025

Mediation of genetic susceptibility to obesity through eating behaviours in children.

Danick Goulet, Michel Boivin, Christopher A Gravel, Julian Little, Beth K Potter, Lise Dubois

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric obesity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Danick GouletSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.ORCID https://orcid.org/0009-0005-7534-6553
Michel BoivinUniversité Laval, Quebec, Quebec, Canada.
Christopher A GravelSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Julian LittleSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Beth K PotterSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Lise DuboisSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.

Funding

CIHR 165964
6 · The paper itself

Abstract

BACKGROUND/

objectivesFew studies have examined the putative mediating role of eating behaviours linking genetic susceptibility and body weight. The goal of this study was to investigate the extent to which two polygenic scores (PGSs) for body mass index (BMI), based on child and adult data, predicted BMI through over-eating and fussy eating across childhood. SUBJECTS/

methodsThe study sample involved 692 participants from a birth cohort study. Height and weight were measured on six occasions between ages 6 and 13 years. Over-eating and fussy eating behaviours were assessed five times between ages 2 and 6 years. Longitudinal growth curve mediation analysis was used to estimate the contributions of the PGSs to BMI z-scores mediated by over-eating and fussy eating.

resultsBoth PGSs predicted BMI z-scores (PGS

conclusionsOur results support the view that appetite is key to translating genetic susceptibility into changes in body weight.

Indexed as

Feeding BehaviorGenetic Predisposition to DiseasePediatric ObesityAdolescentBody Mass IndexBody WeightChildChild, PreschoolFemaleHumansLongitudinal StudiesMaleMultifactorial Inheritancechildren's healtheating behaviourslongitudinal analysismediationobesitypolygenic score

Identifiers

PMID39390328
PMCPMC11936709

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.