Evidence map›Paper›PMID 39390273›Full record

ArticleMolecular imaging and biology2024

Utility of Quantitative Assessment of Tc-99m-diethylenetriamine-penta-acetic acid-galactosyl Human Serum Albumin SPECT/CT in the Identification of Severe Liver Fibrosis: Its Complementary Diagnostic Value with Other Liver Function Indices.

Yoichi Kozaki, Yasutaka Ichikawa, Satoshi Nakamura, Tatsuhiro Kobayashi, Yoya Tomita, Motonori Nagata, Naohisa Kuriyama, Shugo Mizuno, Hajime Sakuma

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Article in Molecular imaging and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Comparison of twoEJNMMI radiopharmacy and chemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yoichi KozakiDepartment of Radiology, Mie University Hospital, 2-174 Edobashi, Tsu, 514-8507, Mie, Japan.
Yasutaka IchikawaDepartment of Radiology, Mie University Hospital, 2-174 Edobashi, Tsu, 514-8507, Mie, Japan. yasutaka@med.mie-u.ac.jp.ORCID 0000-0002-6383-207X
Satoshi NakamuraDepartment of Radiology, Mie University Hospital, 2-174 Edobashi, Tsu, 514-8507, Mie, Japan.
Tatsuhiro KobayashiDepartment of Radiology, Mie University Hospital, 2-174 Edobashi, Tsu, 514-8507, Mie, Japan.
Yoya TomitaDepartment of Radiology, Mie University Hospital, 2-174 Edobashi, Tsu, 514-8507, Mie, Japan.
Motonori NagataDepartment of Radiology, Mie University Hospital, 2-174 Edobashi, Tsu, 514-8507, Mie, Japan.
Naohisa KuriyamaDepartment of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Hospital, 2- 174 Edobashi, Tsu, 514-8507, Mie, Japan.
Shugo MizunoDepartment of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Hospital, 2- 174 Edobashi, Tsu, 514-8507, Mie, Japan.
Hajime SakumaDepartment of Radiology, Mie University Hospital, 2-174 Edobashi, Tsu, 514-8507, Mie, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the value of Tc-99m-diethylenetriamine-penta-acetic acid-galactosyl human serum albumin ( PROCEDURES: Seventy-eight patients with chronic liver disease and hepatocellular carcinoma who underwent

resultsSignificant differences in LUR, LHL15, ICG-R15, ICG-K, platelet count and FIB-4 index were found between the F0-3 and F4 liver fibrosis patient groups (P < 0.05). Multivariate logistic regression analysis revealed that LUR and ICG-K were independent factors for identifying severe liver fibrosis (F4). Area under the curve of receiver operating curve analysis for the logistic regression model using LUR and ICG-K was 0.83. In the patient group with higher FIB-4 (≥ 3.16), the diagnostic performance of LUR for detecting severe liver fibrosis was significantly better than LHL15 (AUC: 0.83 vs. 0.75, P = 0.048). In the high FIB-4 index group, the sensitivity and specificity for identifying F4 was 88% and 85%, respectively, with LUR cutoff value of 41.2%.

conclusionsLUR, measured by

Indexed as

Liver CirrhosisLiver Function TestsSingle Photon Emission Computed Tomography Computed TomographyTechnetium Tc 99m Aggregated AlbuminTechnetium Tc 99m PentetateAdultAgedFemaleHumansLiverMaleMiddle AgedROC CurveTechnetium Tc 99m Aggregated Albumintechnetium Tc 99m DTPA-galactosyl-human serum albuminTechnetium Tc 99m PentetateFIB-4 indexIndocyanine green clearance testLiver fibrosisSingle photon emission tomographyTc-99m-diethylenetriamine-penta-acetic acid-galactosyl human serum albumin

Identifiers

PMID39390273

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.