Evidence map›Paper›PMID 39390257›Full record

ArticleEMBO reports2024

Stress granules are not present in Kras mutant cancers and do not control tumor growth.

Maxime Libert, Sophie Quiquempoix, Jean S Fain, Sébastien Pyr Dit Ruys, Malak Haidar, Margaux Wulleman, Gaëtan Herinckx, Didier Vertommen, Christelle Bouchart, Tatjana Arsenijevic and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. The Role of Long Noncoding RNAs in Modulation of Stress Granules in Cancer.Journal of cellular and molecular medicine · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Emerging roles of stress granules in liver diseases: a comprehensive review.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maxime LibertUniversité catholique de Louvain, de Duve Institute, 1200, Brussels, Belgium.
Sophie QuiquempoixUniversité catholique de Louvain, de Duve Institute, 1200, Brussels, Belgium.
Jean S FainUniversité catholique de Louvain, de Duve Institute, 1200, Brussels, Belgium.
Sébastien Pyr Dit RuysUniversité catholique de Louvain, de Duve Institute, 1200, Brussels, Belgium.ORCID 0000-0002-5449-1541
Malak HaidarUniversité catholique de Louvain, de Duve Institute, 1200, Brussels, Belgium.
Margaux WullemanUniversité catholique de Louvain, de Duve Institute, 1200, Brussels, Belgium.
Gaëtan HerinckxUniversité catholique de Louvain, de Duve Institute, 1200, Brussels, Belgium.ORCID 0000-0002-3050-4459
Didier VertommenUniversité catholique de Louvain, de Duve Institute, 1200, Brussels, Belgium.ORCID 0000-0001-7648-8282
Christelle BouchartDepartment of Radiation Oncology, Jules Bordet Institute, Brussels, Belgium.ORCID 0000-0003-1714-234X
Tatjana ArsenijevicUniversité libre de Bruxelles, Erasme University Hospital, Laboratory of Experimental Gastroenterology, Brussels, Belgium.
Jean-Luc Van LaethemUniversité libre de Bruxelles, Erasme University Hospital, Laboratory of Experimental Gastroenterology, Brussels, Belgium.
Patrick JacqueminUniversité catholique de Louvain, de Duve Institute, 1200, Brussels, Belgium. patrick.jacquemin@uclouvain.be.ORCID 0000-0002-8781-6453

Funding

FRS-FNRS 7.8503.20FRS-FNRS J.0096.21FRS-FNRS J.0097.23Télévie 7.4553.19Télévie 7.6524.21
6 · The paper itself

Abstract

Stress granules (SG) are membraneless ribonucleoprotein-based cytoplasmic organelles that assemble in response to stress. Their formation is often associated with an almost global suppression of translation, and the aberrant assembly or disassembly of these granules has pathological implications in neurodegeneration and cancer. In cancer, and particularly in the presence of oncogenic KRAS mutations, in vivo studies concluded that SG increase the resistance of cancer cells to stress. Hence, SG have recently been considered a promising target for therapy. Here, starting from our observations that genes coding for SG proteins are stimulated during development of pancreatic ductal adenocarcinoma, we analyze the formation of SG during tumorigenesis. We resort to in vitro, in vivo and in silico approaches, using mouse models, human samples and human data. Our analyses do not support that SG are formed during tumorigenesis of KRAS-driven cancers, at least that their presence is not universal, leading us to propose that caution is required before considering SG as therapeutic targets.

Indexed as

MutationProto-Oncogene Proteins p21(ras)Stress GranulesAnimalsCarcinogenesisCarcinoma, Pancreatic DuctalCell Line, TumorCell ProliferationHumansMicePancreatic NeoplasmsKRAS protein, humanProto-Oncogene Proteins p21(ras)CancerKRASPDACStress Granules

Identifiers

PMID39390257
PMCPMC11549491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.