Evidence map›Paper›PMID 39390247›Full record

ReviewNature reviews. Cancer2024

Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells.

Nicolas Rabas, Rute M M Ferreira, Stefania Di Blasio, Ilaria Malanchi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

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  12. Targeting FAPActa pharmaceutica Sinica. B · 2026
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  19. The Five-Decade Journey of Small Cell Lung Cancer.Cancer communications (London, England) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicolas Rabas *Tumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK.
Rute M M Ferreira *Tumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-0053-8348
Stefania Di BlasioTumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK.
Ilaria MalanchiTumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK. Ilaria.Malanchi@crick.ac.uk.ORCID http://orcid.org/0000-0003-4867-3311

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

From their early genesis, tumour cells integrate with the surrounding normal cells to form an abnormal structure that is tightly integrated with the host organism via blood and lymphatic vessels and even neural associations. Using these connections, emerging cancers send a plethora of mediators that efficiently perturb the entire organism and induce changes in distant tissues. These perturbations serendipitously favour early metastatic establishment by promoting a more favourable tissue environment (niche) that supports the persistence of disseminated tumour cells within a foreign tissue. Because the establishment of early metastatic niches represents a key limiting step for metastasis, the creation of a more suitable pre-conditioned tissue strongly enhances metastatic success. In this Review, we provide an updated view of the mechanisms and mediators of primary tumours described so far that induce a pro-metastatic conditioning of distant organs, which favours early metastatic niche formation. We reflect on the nature of cancer-induced systemic conditioning, considering that non-cancer-dependent perturbations of tissue homeostasis are also able to trigger pro-metastatic conditioning. We argue that a more holistic view of the processes catalysing metastatic progression is needed to identify preventive or therapeutic opportunities.

Indexed as

Neoplasm MetastasisNeoplasmsTumor MicroenvironmentAnimalsHumans

Identifiers

PMID39390247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.