Trial reportJournal of perinatology : official journal of the California Perinatal Association2025
Association of delayed cord clamping with acute kidney injury and two-year kidney outcomes in extremely premature neonates: a secondary analysis of the preterm erythropoietin neuroprotection trial (PENUT).
Henry A Zapata, Namrata Todurkar, Kristen Favel, Russell L Griffin, Michelle C Starr, Jennifer R Charlton, Ryan M McAdams, David Askenazi, Tapas Kulkarni, Shina Menon and 2 more
Abstract readRandomized Controlled Trial
In one paragraphTrial report in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors.
Henry A Zapata *University of Florida College of Medicine Jacksonville, Division of Neonatology, Jacksonville, FL, USA.
Kristen FavelUniversity of California San Francisco, Division of Pediatric Nephrology, San Francisco, CA, USA.
Russell L GriffinUniversity of Alabama Birmingham, Department of Epidemiology, Birmingham, AL, USA.
Michelle C StarrIndiana University School of Medicine, Division of Pediatric Nephrology, Indianapolis, IN, USA.ORCID 0000-0001-9412-8950 Jennifer R CharltonUniversity of Virginia, Department of Pediatrics, Charlottesville, VA, USA.
David AskenaziUniversity of Alabama Birmingham, Department of Pediatrics, Birmingham, AL, USA.
Tapas KulkarniUniversity of British Columbia, Department of Pediatrics, Vancouver, BC, Canada.
Shina MenonStanford University, Department of Pediatrics, Division of Pediatric Nephrology, Palo Alto, CA, USA.
Cherry MammenUniversity of British Columbia, Department of Pediatrics, Vancouver, BC, Canada.
Matthew W HarerUniversity of Wisconsin, Division of Neonatology, Madison, WI, USA. mwharer@wisc.edu.ORCID 0000-0001-5493-3269 Funding
Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI ROBERTO Ariel GOMEZ · 2012 to 2026
$13.8MPreterm Epo Neuroprotection Trial (PENUT Trial) CCCU01NS077953 · NINDS · UNIVERSITY OF WASHINGTON · PI JUUL, SANDRA E · 2013 to 2018
$10.7MRecombinant Erythropoietin for Protection of Infant Renal Disease(REPAIReD)R01DK103608 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI ASKENAZI, DAVID JOSEPH, GOLDSTEIN, STUART L · 2014 to 2019
$3.0MInvestigating the effect of dysregulated vitamin D metabolism on kidney development following preterm birthR01DK136989 · NIDDK · UNIVERSITY OF VIRGINIA · PI Jennifer R Charlton, Kimberly Jean Reidy · 2024 to 2026
$2.1MComprehensive MRI-based evaluation of human renal microstructureR01DK111861 · NIDDK · UNIVERSITY OF VIRGINIA · PI BENNETT, KEVIN M, CHARLTON, JENNIFER R · 2017 to 2020
$1.8MPreterm Epo Neuroprotection Trial (PENUT Trial) DCCU01NS077955 · NINDS · UNIVERSITY OF WASHINGTON · PI HEAGERTY, PATRICK J · 2013 to 2018
$1.5MNoninvasive MRI techniques to detect pathology in murine models of renal diseaseR01DK110622 · NIDDK · WASHINGTON UNIVERSITY · PI BENNETT, KEVIN M, CHARLTON, JENNIFER R · 2017 to 2019
$1.0MInvestigating the role of nephron mass in the progression of CKD using MRIR56DK110622 · NIDDK · WASHINGTON UNIVERSITY · PI BENNETT, KEVIN M, CHARLTON, JENNIFER R · 2021 to 2021
$100kNIDDK NIH HHS P50 DK096373NIDDK NIH HHS R01 DK103608NIDDK NIH HHS R01 DK110622NIDDK NIH HHS R01 DK111861NIDDK NIH HHS R01 DK136989NIDDK NIH HHS R56 DK110622NINDS NIH HHS U01 NS077953NINDS NIH HHS U01 NS077955
6 · The paper itselfAbstract
backgroundDelayed cord clamping (DCC) occurs in most preterm births.
objectiveEvaluate the association of DCC with acute kidney injury (AKI) and two-year kidney outcomes.
methodsSecondary analysis of the Preterm Erythropoietin Neuroprotection Trial of neonates born 24
resultsThe incidence and severity of AKI did not differ between the DCC and ECC groups (aOR 1.17 [95%CI 0.76-1.80]). At two years corrected age, DCC was associated with a 4.5-fold increased adjusted odds of estimated glomerular filtration rate (eGFR) <90 mL/min/1.73m
conclusionsDCC was not associated with decreased neonatal AKI, but was associated with higher adjusted odds of eGFR <90 mL/min/1.73m
Indexed as
Acute Kidney InjuryErythropoietinGlomerular Filtration RateInfant, Extremely PrematureUmbilical Cord ClampingFemaleGestational AgeHumansIncidenceInfant, NewbornMalePregnancyTime FactorsUmbilical CordErythropoietin
Identifiers
PMID39390245
PMCPMC11881105
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