Evidence map›Paper›PMID 39390228›Full record

Observational studyClinical oral investigations2024

Protein profile at newly restored implants compared to contralateral teeth over 12-months: a pilot study.

Danae A Apatzidou, Anastasia Violesti, Antonis Konstantinidis, Kai Bao, Angelika Silbereisen, Nagihan Bostanci

Registry-linked trialAbstract readComparative StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06379022 (Clinical and Cellular Responses of Tissues at Newly Restored Single Implants Compared to Contralateral Natural Teeth During Their First Year of Functional Loading), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06379022 completednot on this map

Clinical and Cellular Responses of Tissues at Newly Restored Single Implants Compared to Contralateral Natural Teeth During Their First Year of Functional Loading

Typeobservational_patient_registrySponsorAristotle University Of ThessalonikiRan2018 to 2019Enrolled10ConditionsPeri-Implantitis, Peri-implant Mucositis, Periodontal DiseasesArmsPlaque control
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Danae A ApatzidouDepartment of Preventive Dentistry, Periodontology and Implant Biology, Faculty of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece. perioapatzidou@yahoo.gr.
Anastasia ViolestiDepartment of Preventive Dentistry, Periodontology and Implant Biology, Faculty of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Antonis KonstantinidisDepartment of Preventive Dentistry, Periodontology and Implant Biology, Faculty of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Kai BaoDivision of Oral Health and Periodontology, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
Angelika SilbereisenDivision of Oral Health and Periodontology, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
Nagihan BostanciDivision of Oral Health and Periodontology, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine crevicular fluid alterations in protein expression of newly restored implants during their first year of function and associate them with those of contralateral teeth. MATERIALS AND

methodsIn ten non-smokers, successfully treated for periodontitis, one newly restored implant (baseline-T0) and one corresponding tooth were followed for 12-months (T1). Oral hygiene was monitored during the study. Periodontal clinical indices and crevicular fluid were collected from an implant-site (PICF) and a tooth-site (GCF). Total proteomic profiles of PICF and GCF were investigated using label-free quantitative proteomics.

resultsClinical recordings remained stable at 12-months on the tooth-/implant-site basis. The comparative analysis of protein enrichment between teeth and implants at T0 revealed 664 human proteins, with 93 found only in teeth and 217 exclusively in implants. Among the 354 overlapping proteins, 46 were upregulated (log

conclusionsPeri-implant tissue maturation was evident during the study. Proteins expressed in crevicular fluid reflected unique patterns between implants and teeth that are worth studying. CLINICAL RELEVANCE: Different proteomic patterns were observed at the implant-site compared to the contralateral tooth-site towards inflammatory processes that prevail within otherwise clinically healthy peri-implant tissues. CLINICAL TRIAL REGISTRATION NUMBER: ClinicalTrials.gov ID: NCT06379022.

Indexed as

Dental ImplantsGingival Crevicular FluidProteomicsAdultFemaleHumansMaleMiddle AgedPeriodontal IndexPeriodontitisPilot ProjectsDental ImplantsClinical indicesCrevicular fluidFirst year of functionInflammationPeri-implant tissueProteomicsTissue remodeling

Identifiers

PMID39390228

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.