Evidence map›Paper›PMID 39390075›Full record

ArticleCommunications biology2024

Loss of adipose ATF3 promotes adipose tissue lipolysis and the development of MASH.

Shuwei Hu, Fathima N Cassim Bawa, Yingdong Zhu, Xiaoli Pan, Hui Wang, Raja Gopoju, Yanyong Xu, Yanqiao Zhang

Abstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuwei Hu *Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Fathima N Cassim Bawa *Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Yingdong Zhu *Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Xiaoli PanDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Hui WangDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Raja GopojuDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Yanyong XuDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Yanqiao ZhangDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA. yzhang8@arizona.edu.ORCID 0000-0002-1886-7775

Funding

Forkhead Box A3 and Bile Acid MetabolismR01DK121548 · NIDDK · UNIVERSITY OF ARIZONA · PI ZHANG, YANQIAO · 2020 to 2023
$2.1M
Identification of Novel Genes/Pathways That Regulate AtherogenesisR01HL142086 · NHLBI · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, YANQIAO · 2018 to 2021
$2.1M
Hepatic FOXA3 Links NAFLD to AtherosclerosisR01DK118805 · NIDDK · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, YANQIAO · 2019 to 2022
$2.0M
Role of Hepatocyte ATF3 in NAFLDR01DK118941 · NIDDK · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, YANQIAO · 2018 to 2021
$1.8M
NHLBI NIH HHS R01 HL142086NIDDK NIH HHS R01 DK118805NIDDK NIH HHS R01 DK118941NIDDK NIH HHS R01 DK121548U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL142086, R01DK118941, R01DK118805, and R01DK121548
6 · The paper itself

Abstract

The crosstalk between adipose tissue and the liver is finely controlled to maintain metabolic health. Yet, how adipose tissue controls toxic free fatty acid overflow into the liver remains incompletely understood. Here, we show that adipocyte activating transcription factor 3 (ATF3) was induced in human or mouse obesity. Adipocyte Atf3

Indexed as

Activating Transcription Factor 3Adipose TissueLipolysisMice, KnockoutAdipocytesAnimalsDiet, High-FatEnergy MetabolismFatty LiverFemaleHumansLipogenesisMaleMiceMice, Inbred C57BLObesityActivating Transcription Factor 3ATF3 protein, humanAtf3 protein, mouse

Identifiers

PMID39390075
PMCPMC11467330

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.