Evidence map›Paper›PMID 39390011›Full record

ArticleScientific reports2024

Dysbiotic signatures and diagnostic potential of gut microbial markers for inflammatory bowel disease in Korean population.

Hyun Sik Kim, Shin Ju Oh, Byung Kwon Kim, Ji Eun Kim, Bo-Hyung Kim, Young-Kyu Park, Bo-Gie Yang, Jae-Yun Lee, Jin-Woo Bae, Chang Kyun Lee

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hyun Sik Kim *Department of Biology, Kyung Hee University, Seoul, Republic of Korea.
Shin Ju Oh *Department of Gastroenterology, Center for Crohn's and Colitis, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Byung Kwon Kim *Research Institute, GI Biome Inc., Seongnam, Republic of Korea.
Ji Eun KimDepartment of Gastroenterology, Center for Crohn's and Colitis, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Bo-Hyung KimDepartment of Clinical Pharmacology and Therapeutics, Kyung Hee University Hospital, Seoul, Republic of Korea.
Young-Kyu ParkResearch Institute, GI Biome Inc., Seongnam, Republic of Korea.
Bo-Gie YangResearch Institute, GI Biome Inc., Seongnam, Republic of Korea.
Jae-Yun LeeDepartment of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.
Jin-Woo BaeDepartment of Biology, Kyung Hee University, Seoul, Republic of Korea. baejw@khu.ac.kr.
Chang Kyun LeeDepartment of Gastroenterology, Center for Crohn's and Colitis, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea. gidrlee@gmail.com.

Funding

Korea Health Industry Development Institute HI23C0661National Research Foundation of Korea 2017R1A5A2014768National Research Foundation of Korea 2021R1C1C2008556
6 · The paper itself

Abstract

Fecal samples were collected from 640 individuals in Korea, including 523 patients with IBD (223 with Crohn's disease [CD] and 300 with ulcerative colitis [UC]) and 117 healthy controls. The samples were subjected to cross-sectional gut metagenomic analysis using 16 S rRNA sequencing and bioinformatics analysis. Patients with IBD, particularly those with CD, exhibited significantly lower alpha diversities than the healthy subjects. Differential abundance analysis revealed dysbiotic signatures, characterized by an expansion of the genus Escherichia-Shigella in patients with CD. Functional annotations showed that functional pathways related to bacterial pathogenesis and production of hydrogen sulfide (H

Indexed as

BiomarkersDysbiosisFecesGastrointestinal MicrobiomeInflammatory Bowel DiseasesRNA, Ribosomal, 16SAdultAgedCase-Control StudiesColitis, UlcerativeCrohn DiseaseCross-Sectional StudiesFemaleHumansMaleMetagenomicsBiomarkersRNA, Ribosomal, 16S

Identifiers

PMID39390011
PMCPMC11467411

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.