ArticleBJOG : an international journal of obstetrics and gynaecology2025
Unilateral Oophorectomy and Age at Natural Menopause: A Longitudinal Community-Based Cohort Study.
Article in BJOG : an international journal of obstetrics and gynaecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Evaluation of the IOTA ADNEX Model, Two-Step Strategy and RMI in Routine Gynaecologic Care in Denmark and Implications for Implementation: A Prospective Multicenter Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Age at Menopause and Trajectories of Multimorbidity Progression to Mortality: A Multi-State Analysis of UK Biobank Data.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Incidence and Outcomes of Surgically Managed Ectopic Pregnancy in Women With Disabilities: A Population-Based Cross-Sectional Study.Paediatric and perinatal epidemiology · 2026Article
- The association of infertility, miscarriage, stillbirth, and parity with osteoporosis: a pooled analysis of five cohort studies.Fertility and sterility · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
objectiveTo determine the association between unilateral oophorectomy (UO) and age at natural menopause.
designSecondary analysis of survey data from Alberta's Tomorrow Project (2000-2022).
settingProspective cohort study in Alberta, Canada. POPULATION: 23 630 women; 548 experienced UO and 23 082 did not experience UO.
methodsFlexible parametric survival analysis was used to analyse age at natural menopause, and logistic regression was used to analyse early menopause and premature ovarian insufficiency by UO status, controlling for birth year, parity, age at menarche, past infertility, hormonal contraceptive use and smoking.
main outcome measuresAge at natural menopause occurred by a final menstrual period without medical cause and sub-classified as early menopause (< 45 years) and premature ovarian insufficiency (< 40 years).
resultsCompared to no UO, any UO was associated with elevated risk of earlier age at natural menopause, which was strongest in early midlife (adjusted HR at age 40 1.71, 95% CI 1.31-2.19) and diminished over time. Compared to age 55 years at UO, risks of earlier age at natural menopause were largest and uniform in magnitude when UO occurred between approximately ages 20-40 years (adjusted HR for UO at age 30 2.32, 1.46-3.54) and then diminished as age at UO approached the average age at natural menopause. Any UO was associated with higher odds of early menopause (adjusted OR 1.90, 1.30-2.79) and premature ovarian insufficiency (adjusted OR 3.75, 1.72-8.16).
conclusionsUnilateral oophorectomy is associated with earlier age at natural menopause, particularly when performed before 40 years of age.
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